ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> ADURO BIOTECH HOLDINGS, EUROPE B.V. <120> Антитела против SIRP-альфа <130> ABE-0007-UT <140> US 15/953,201 <141> 2018-04-13 <150> NL 2018708 <151> 2017-04-13 <150> NL 2019166 <151> 2017-07-03 <160> 135 <170> PatentIn версии 3.5 <210> 1 <211> 5 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR1 тяжелой цепи 50A <400> 1 Asn Tyr Tyr Ile His 1 5 <210> 2 <211> 17 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR2 тяжелой цепи 50A <400> 2 Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 1 5 10 15 Ala <210> 3 <211> 10 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR3 тяжелой цепи 50A <400> 3 Pro Thr Ile Ile Ala Thr Asp Phe Asp Val 1 5 10 <210> 4 <211> 11 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR1 легкой цепи 50A <400> 4 Lys Ala Ser Gln Gly Val Gly Thr Ala Val Gly 1 5 10 <210> 5 <211> 7 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR2 легкой цепи 50A <400> 5 Trp Ala Ser Thr Arg His Thr 1 5 <210> 6 <211> 9 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR3 легкой цепи 50A <400> 6 Gln Gln Tyr Ser Thr Tyr Pro Phe Thr 1 5 <210> 7 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Вариабельная область тяжелой цепи гуманизированного антитела 50 (консенсусная последовательность) <220> <221> misc_feature <222> (5)..(5) <223> X = Q или V <220> <221> misc_feature <222> (6)..(6) <223> X = Q или E <220> <221> misc_feature <222> (9)..(9) <223> X = A или S <220> <221> misc_feature <222> (11)..(11) <223> X = V или L <220> <221> misc_feature <222> (19)..(19) <223> X = K или M <220> <221> misc_feature <222> (20)..(20) <223> X = V или I <220> <221> misc_feature <222> (40)..(40) <223> X = A или R <220> <221> misc_feature <222> (42)..(42) <223> X = G или E <220> <221> misc_feature <222> (48)..(48) <223> X = I или M <220> <221> misc_feature <222> (67)..(67) <223> X = R или K <220> <221> misc_feature <222> (68)..(68) <223> X = V или A <220> <221> misc_feature <222> (69)..(69) <223> X = T или I <220> <221> misc_feature <222> (70)..(70) <223> X = I или M <220> <221> misc_feature <222> (79)..(79) <223> X = A или V <220> <221> misc_feature <222> (82)..(82) <223> X = D, или E, или Q <220> <221> misc_feature <222> (87)..(87) <223> X = R или T <220> <221> misc_feature <222> (89)..(89) <223> X = E или D <220> <221> misc_feature <222> (91)..(91) <223> X = T или M <220> <221> misc_feature <222> (114)..(114) <223> X = T или L <400> 7 Glu Val Gln Leu Xaa Xaa Ser Gly Xaa Glu Xaa Val Lys Pro Gly Ala 1 5 10 15 Ser Val Xaa Xaa Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Xaa Pro Xaa Gln Gly Leu Glu Trp Xaa 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Xaa Xaa Xaa Xaa Thr Ala Asp Lys Ser Thr Ser Thr Xaa Tyr 65 70 75 80 Met Xaa Leu Ser Ser Leu Xaa Ser Xaa Asp Xaa Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Xaa Val Thr Val Ser Ser 115 <210> 8 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Вариабельная область легкой цепи гуманизированного антитела 50 (консенсусная последовательность) <220> <221> misc_feature <222> (1)..(4) <223> X = D или E <220> <221> misc_feature <222> (2)..(2) <223> X = I или L <220> <221> misc_feature <222> (3)..(3) <223> X = V или Q <220> <221> misc_feature <222> (4)..(4) <223> X = L или M <220> <221> misc_feature <222> (10)..(10) <223> X = F или S <220> <221> misc_feature <222> (38)..(38) <223> X = Q или K <220> <221> misc_feature <222> (43)..(43) <223> X = A, или S, или V <220> <221> misc_feature <222> (70)..(70) <223> X = E или D <220> <221> misc_feature <222> (74)..(74) <223> X = T или A <220> <221> misc_feature <222> (76)..(76) <223> X = S или N <220> <221> misc_feature <222> (77)..(77) <223> X = S, или N, или G <220> <221> misc_feature <222> (83)..(83) <223> X = F, или I, или V <220> <221> misc_feature <222> (85)..(85) <223> X = A, или D, или T <220> <221> misc_feature <222> (104)..(104) <223> X = L или V <400> 8 Xaa Xaa Xaa Xaa Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Xaa Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Xaa Phe Thr Leu Xaa Ile Xaa Xaa Leu Gln Pro 65 70 75 80 Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 100 105 <210> 9 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH1 hSIRP-альфа.50A <400> 9 gaagtgcagc tgcagcagtc tggcgccgag gtcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg cctccggctt caccttcacc aactactaca tccactgggt gcgacaggcc 120 ccaggccagg gactggaatg gatcggctgg atctaccccg gcaacgtgaa caccaagtac 180 aacgagaagt tcaaggcccg cgtgaccatc accgccgaca agtctacctc caccgcctac 240 atggacctgt cctccctgag atccgaggac accgccgtgt actactgcgc cagacccacc 300 atcattgcca ccgacttcga cgtgtggggc cagggcacaa ccgtgaccgt gtcctct 357 <210> 10 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH1 hSIRP-альфа.50A <400> 10 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 11 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH2 hSIRP-альфа.50A <400> 11 gaagtgcagc tggtggaatc cggctccgag ctcgtgaagc ctggcgcctc cgtgaaggtg 60 tcctgcaagg cctctggctt caccttcacc aactactaca tccactgggt gcgacaggcc 120 ccaggccagg gactggaatg gatgggctgg atctaccccg gcaacgtgaa caccaagtac 180 aacgagaagt tcaaggccaa ggccaccatc accgccgaca agtccacctc caccgcctac 240 atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgtgc ccggcctacc 300 atcattgcca ccgacttcga tgtgtggggc cagggcacac tcgtgaccgt gtcctct 357 <210> 12 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH2 hSIRP-альфа.50A <400> 12 Glu Val Gln Leu Val Glu Ser Gly Ser Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 13 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH3 hSIRP-альфа.50A <400> 13 gaagtgcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc cgtgatgatc 60 tcctgcaagg cctccggctt caccttcacc aactactaca tccactgggt gcgacagcgg 120 ccaggccagg gactggaatg gatcggctgg atctaccccg gcaacgtgaa caccaagtac 180 aacgagaagt tcaaggcccg cgtgatcatg accgccgaca agtccacctc caccgtgtac 240 atgcagctgt cctccctgac ctccgaggac accgccgtgt actactgcgc cagacccacc 300 atcattgcca ccgacttcga cgtgtggggc cagggcacac tcgtgaccgt gtcctct 357 <210> 14 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH3 hSIRP-альфа.50A <400> 14 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Met Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Arg Val Ile Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 15 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH4 hSIRP-альфа.50A <400> 15 gaagtgcagc tgcagcagtc tggcgccgag ctcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg cctccggctt caccttcacc aactactaca tccactgggt gcgacagcgg 120 ccaggccagg gactggaatg gatgggctgg atctaccccg gcaacgtgaa caccaagtac 180 aacgagaagt tcaaggccaa ggccaccatc accgccgaca agtccacctc caccgcctac 240 atggaactgt cctccctgac ctccgaggac accgccgtgt actactgcgc cagacccacc 300 atcattgcca ccgacttcga cgtgtggggc cagggcacaa ccgtgaccgt gtcctct 357 <210> 16 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH4 hSIRP-альфа.50A <400> 16 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 17 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH5 hSIRP-альфа.50A <400> 17 gaagtgcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg cctccggctt caccttcacc aactactaca tccactgggt gcgacaggcc 120 cccgagcagg gactggaatg gatcggctgg atctaccccg gcaacgtgaa caccaagtac 180 aacgagaagt tcaaggcccg cgtgaccatg accgccgaca agtctacctc caccgcctac 240 atggaactgt cctccctgcg gagcgacgac atggccgtgt actactgcgc cagacccacc 300 atcattgcca ccgacttcga cgtgtggggc cagggcacaa ccgtgaccgt gtcctct 357 <210> 18 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH5 hSIRP-альфа.50A <400> 18 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 19 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL1 hSIRP-альфа.50A <400> 19 gacatcgtgc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc 60 atcacatgca aggcctctca gggcgtgggc accgctgtgg gatggtatca gcagaagcct 120 ggcaaggccc ccaagctgct gatctactgg gcctctacca gacacaccgg cgtgcccgac 180 agattctccg gctctggctc tggcaccgag tttaccctga ccatctccag cctgcagccc 240 gaggatttcg ccgcctacta ctgccagcag tactccacct accccttcac cttcggcgga 300 ggcaccaagc tggaaatcaa g 321 <210> 20 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL1 hSIRP-альфа.50A <400> 20 Asp Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 21 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL2 hSIRP-альфа.50A <400> 21 gacatcgtga tgacccagtc cccctccagc ctgtctgcct ctgtgggcga cagagtgacc 60 atcacatgca aggcctctca gggcgtgggc accgctgtgg gatggtatca gcagaagcct 120 ggcaaggccc ccaagctgct gatctactgg gcctctacca gacacaccgg cgtgcccgac 180 agattctccg gctctggctc tggcaccgac ttcaccctga ccatctccaa cctgcagccc 240 gaggacttcg ccgactacta ctgccagcag tactccacct accccttcac cttcggcgga 300 ggcaccaagg tggaaatcaa g 321 <210> 22 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL2 hSIRP-альфа.50A <400> 22 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 23 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL3 hSIRP-альфа.50A <400> 23 gagctcgtga tgacccagtc cccttccagc ctgtctgcct ccgtgggcga cagagtgacc 60 atcacatgca aggcctctca gggcgtgggc accgctgtgg gatggtatca gcagaagcct 120 ggcaaggccc ccaagctgct gatctactgg gcctctacca gacacaccgg cgtgcccgac 180 agattctccg gctctggctc tggcaccgac tttaccctgg ccatctccag cctgcagccc 240 gaggatatcg ccgactacta ctgccagcag tactccacct accccttcac cttcggcgga 300 ggcaccaagg tggaaatcaa g 321 <210> 24 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL3 hSIRP-альфа.50A <400> 24 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 25 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL4 hSIRP-альфа.50A <400> 25 gacatccaga tgacccagtc cccctccagc ctgtctgcct ctgtgggcga cagagtgacc 60 atcacatgca aggcctctca gggcgtgggc accgctgtgg gctggtatca gaaaaagccc 120 ggcaaggtgc ccaagctgct gatctactgg gcctccacca gacacaccgg cgtgcccgat 180 agattctccg gctctggctc tggcaccgac ttcaccctga ccatcaacgg cctgcagcct 240 gaggacgtgg ccacctacta ctgccagcag tactccacct accccttcac cttcggcgga 300 ggcaccaagc tggaaatcaa g 321 <210> 26 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL4 hSIRP-альфа.50A <400> 26 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Lys Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 27 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL5 hSIRP-альфа.50A <400> 27 gacatcgtgc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc 60 atcacatgca aggcctctca gggcgtgggc accgctgtgg gatggtatca gcagaagccc 120 ggcaagtccc ccaagctgct gatctactgg gcctccacca gacacaccgg cgtgcccgat 180 agattctccg gctctggctc tggcaccgag ttcaccctga ccatctccaa cctgcagccc 240 gaggacttcg ccgcctacta ctgccagcag tactccacct accccttcac cttcggcgga 300 ggcaccaagc tggaaatcaa g 321 <210> 28 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL5 hSIRP-альфа.50A <400> 28 Asp Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 29 <211> 357 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH мыши hSIRP-альфа.50A <400> 29 caggtccagc tgcagcagtc tggacctgaa ctggtgaagc ctggggcttc agttaggata 60 tcctgcaagg cttctggctt caccttcaca aactactata tacactgggt gaagcagagg 120 cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac 180 aatgagaagt tcaaggccaa ggccacactg actgcagaca aatcctccac cacagcctac 240 atgcagctca gcagcctggc ctctgaggac tctgcggtct atttctgtgc aagacctacg 300 ataatagcta cggacttcga tgtctggggc gcagggacca cggtcaccgt ctcctca 357 <210> 30 <211> 119 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH мыши hSIRP-альфа.50A <400> 30 Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Pro Thr Ile Ile Ala Thr Asp Phe Asp Val Trp Gly Ala Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 31 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL мыши hSIRP-альфа.50A <400> 31 gacattgtca tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaac 60 atcacctgca aggccagtca gggtgtgggt actgctgtag gctggtatca acagaaacca 120 gggcaatctc ctagactact gatttactgg gcatccaccc ggcacactgg agtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcagtctcg ccattagcaa tgtgcagtct 240 gaagacctgg cagattattt ctgtcagcaa tatagcacct atccgttcac gttcggaggg 300 gggaccaatc tagaaataaa a 321 <210> 32 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL мыши hSIRP-альфа.50A <400> 32 Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Thr Ala 20 25 30 Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ser Leu Ala Ile Ser Asn Val Gln Ser 65 70 75 80 Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 100 105 <210> 33 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V1 человека <400> 33 atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc 60 gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac 120 aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg 180 atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac 240 aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac 300 aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac 360 tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact 420 gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc 480 acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc 540 accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc 600 gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag 660 gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt 720 cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa 780 cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc 840 cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca 900 accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta 960 tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg 1020 gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc 1080 gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc 1140 accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa 1200 gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata 1260 acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct 1320 gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg 1380 cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg 1440 acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag 1500 gtcccgagga ag 1512 <210> 34 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V1 человека <400> 34 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 35 <211> 1509 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1509) <223> SIRP-альфа V2 человека <400> 35 atggaacctg ccggacctgc ccctggcaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagagcgtgt ccgtggctgc tggcgagtct gccatcctgc actgtaccgt gaccagcctg 180 atccccgtgg gccccatcca gtggtttaga ggcgctggcc ctgccagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgagagcac caagcgcgag 300 aacatggact tcagcatcag catctccaac atcacccctg ccgacgccgg cacctactac 360 tgcgtgaagt tcagaaaggg cagccccgac accgagttca agagcggcgc tggaaccgag 420 ctgtctgtgc gggctaagcc ttctgcccct gtggtgtctg gacctgccgc cagagctaca 480 cctcagcaca ccgtgtcttt cacatgcgag agccacggct tcagccccag agacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg agcgacttcc agaccaacgt ggaccctgtg 600 ggcgagtccg tgtcctacag catccacagc accgccaagg tggtgctgac ccgcgaggat 660 gtgcacagcc aagtgatctg cgaggtggcc cacgtgacac tgcagggcga tcctctgaga 720 ggcaccgcta acctgagcga gacaatcaga gtgcccccca ccctggaagt gacccagcag 780 cccgtgcggg ctgagaacca agtgaacgtg acctgccaag tgcggaagtt ctaccctcag 840 agactgcagc tgacctggct ggaaaacgga aacgtgtcca gaaccgagac agccagcacc 900 gtgacagaga acaaggacgg cacatacaac tggatgagct ggctgctcgt gaacgtgtcc 960 gcccacagag atgacgtgaa gctgacatgc caggtggaac acgacggcca gcctgccgtg 1020 tctaagagcc acgacctgaa ggtgtccgct caccccaaag agcagggcag caacaccgcc 1080 gctgagaaca caggcagcaa cgagagaaac atctacatcg tcgtgggcgt cgtgtgcacc 1140 ctgctggtgg ctctgctgat ggctgccctg tacctcgtgc ggatcagaca gaagaaggcc 1200 cagggctcca cctccagcac cagactgcac gagcctgaga agaacgcccg cgagatcacc 1260 caggacacca acgacatcac ctacgccgac ctgaacctgc ccaagggcaa gaagcctgcc 1320 cctcaggctg ccgagcctaa caaccacaca gagtacgcca gcatccagac cagccctcag 1380 cctgccagcg aggacacact gacatacgcc gatctggaca tggtgcacct gaacagaacc 1440 cccaagcagc ccgctcccaa gcccgagcct agcttctctg agtacgcctc cgtgcaggtg 1500 cccagaaaa 1509 <210> 36 <211> 503 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(503) <223> SIRP-альфа V2 человека <400> 36 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 35 40 45 Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 85 90 95 Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 145 150 155 160 Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 260 265 270 Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 305 310 315 320 Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 340 345 350 Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 355 360 365 Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala 370 375 380 Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala 385 390 395 400 Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala 405 410 415 Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn 420 425 430 Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn 435 440 445 His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser Glu 450 455 460 Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg Thr 465 470 475 480 Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr Ala 485 490 495 Ser Val Gln Val Pro Arg Lys 500 <210> 37 <211> 1194 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1194) <223> SIRP-бета 1 человека <400> 37 atgcccgtgc cagcctcctg gccccacctt cctagtcctt tcctgctgat gacgctactg 60 ctggggagac tcacaggagt ggcaggtgag gacgagctac aggtgattca gcctgaaaag 120 tccgtatcag ttgcagctgg agagtcggcc actctgcgct gtgctatgac gtccctgatc 180 cctgtggggc ccatcatgtg gtttagagga gctggagcag gccgggaatt aatctacaat 240 cagaaagaag gccacttccc acgggtaaca actgtttcag aactcacaaa gagaaacaac 300 ctggactttt ccatcagcat cagtaacatc accccagcag acgccggcac ctactactgt 360 gtgaagttcc ggaaagggag ccctgacgac gtggagttta agtctggagc aggcactgag 420 ctgtctgtgc gcgccaaacc ctctgccccc gtggtatcgg gccctgcggt gagggccaca 480 cctgagcaca cagtgagctt cacctgcgag tcccatggct tctctcccag agacatcacc 540 ctgaaatggt tcaaaaatgg gaatgagctc tcagacttcc agaccaacgt ggaccccgca 600 ggagacagtg tgtcctacag catccacagc acagccaggg tggtgctgac ccgtggggac 660 gttcactctc aagtcatctg cgagatagcc cacatcacct tgcaggggga ccctcttcgt 720 gggactgcca acttgtctga ggccatccga gttccaccca ccttggaggt tactcaacag 780 cccatgaggg cagagaacca ggcaaacgtc acctgccagg tgagcaattt ctacccccgg 840 ggactacagc tgacctggtt ggagaatgga aatgtgtccc ggacagaaac agcttcgacc 900 ctcatagaga acaaggatgg cacctacaac tggatgagct ggctcctggt gaacacctgt 960 gcccacaggg acgatgtggt gctcacctgt caggtggagc atgatgggca gcaagcagtc 1020 agcaaaagct atgccctgga gatctcagcg caccagaagg agcacggctc agatatcacc 1080 catgaagcag cgctggctcc tactgctcca ctcctcgtag ctctcctcct gggccccaag 1140 ctgctactgg tggttggtgt ctctgccatc tacatctgct ggaaacagaa ggcc 1194 <210> 38 <211> 398 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(398) <223> SIRP-бета 1 человека <400> 38 Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 1 5 10 15 Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 20 25 30 Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 35 40 45 Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 50 55 60 Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 65 70 75 80 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 85 90 95 Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 100 105 110 Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 115 120 125 Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 145 150 155 160 Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 260 265 270 Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 305 310 315 320 Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 340 345 350 Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 355 360 365 Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 370 375 380 Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 385 390 395 <210> 39 <211> 1161 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1161) <223> SIRP-гамма человека <400> 39 atgcctgtcc cagcctcctg gccccatcct cctggtcctt tcctgcttct gactctactg 60 ctgggactta cagaagtggc aggtgaggag gagctacaga tgattcagcc tgagaagctc 120 ctgttggtca cagttggaaa gacagccact ctgcactgca ctgtgacctc cctgcttccc 180 gtgggacccg tcctgtggtt cagaggagtt ggaccaggcc gggaattaat ctacaatcaa 240 aaagaaggcc acttccccag ggtaacaaca gtttcagacc tcacaaagag aaacaacatg 300 gacttttcca tccgcatcag tagcatcacc ccagcagatg tcggcacata ctactgtgtg 360 aagtttcgaa aagggagccc tgagaacgtg gagtttaagt ctggaccagg cactgagatg 420 gctttgggtg ccaaaccctc tgcccccgtg gtattgggcc ctgcggcgag gaccacacct 480 gagcatacag tgagtttcac ctgtgagtcc catggcttct ctcccagaga catcaccctg 540 aaatggttca aaaatgggaa tgagctctca gacttccaga ccaacgtgga ccccacagga 600 cagagtgtgg cctacagcat ccgcagcaca gccagggtgg tactggaccc ctgggacgtt 660 cgctctcagg tcatctgcga ggtggcccat gtcaccttgc agggggaccc tcttcgtggg 720 actgccaact tgtctgaggc catccgagtt ccacccacct tggaggttac tcaacagccc 780 atgagggtgg ggaaccaggt aaacgtcacc tgccaggtga ggaagttcta cccccagagc 840 ctacagctga cctggtcgga gaatggaaac gtgtgccaga gagaaacagc ctcgaccctt 900 acagagaaca aggatggtac ctacaactgg acaagctggt tcctggtgaa catatctgac 960 caaagggatg atgtggtcct cacctgccag gtgaagcatg atgggcagct ggcggtcagc 1020 aaacgccttg ccctagaggt cacagtccac cagaaggacc agagctcaga tgctacccct 1080 ggcccggcat catcccttac tgcgctgctc ctcatagctg tcctcctggg ccccatctac 1140 gtcccctgga agcagaagac c 1161 <210> 40 <211> 387 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(387) <223> SIRP-гамма человека <400> 40 Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 1 5 10 15 Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 20 25 30 Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 35 40 45 Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 50 55 60 Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 65 70 75 80 Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 85 90 95 Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 100 105 110 Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 115 120 125 Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 130 135 140 Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 145 150 155 160 Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 165 170 175 Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 180 185 190 Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 195 200 205 Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 210 215 220 Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 225 230 235 240 Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu Val 245 250 255 Thr Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys Gln 260 265 270 Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu Asn 275 280 285 Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys 290 295 300 Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser Asp 305 310 315 320 Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly Gln 325 330 335 Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln Lys 340 345 350 Asp Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ser Leu Thr Ala 355 360 365 Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp Lys 370 375 380 Gln Lys Thr 385 <210> 41 <211> 969 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(969) <223> CD47 человека <400> 41 atgtggcctc tggtggccgc tctgctgctg ggctctgctt gttgtggatc cgcccagctg 60 ctgttcaaca agaccaagtc cgtggagttc accttctgca acgataccgt cgtgatcccc 120 tgcttcgtga ccaacatgga agcccagaac accaccgagg tgtacgtgaa gtggaagttc 180 aagggccggg acatctacac cttcgacggc gccctgaaca agtccaccgt gcccaccgat 240 ttctccagcg ccaagatcga ggtgtcacag ctgctgaagg gcgacgcctc cctgaagatg 300 gacaagtccg acgccgtgtc ccacaccggc aactacacct gtgaagtgac cgagctgacc 360 agagagggcg agacaatcat cgagctgaag taccgggtgg tgtcctggtt cagccccaac 420 gagaacatcc tgatcgtgat cttccccatc ttcgccatcc tgctgttctg gggccagttc 480 ggcatcaaga ccctgaagta cagatccggc ggcatggacg aaaagacaat cgccctgctg 540 gtggctggcc tcgtgatcac cgtgattgtg atcgtgggcg ctatcctgtt cgtgcccggc 600 gagtacagcc tgaagaatgc taccggcctg ggcctgattg tgacctccac cggaatcctg 660 atcctgctgc actactacgt gttctccacc gctatcggcc tgacctcctt cgtgatcgcc 720 attctcgtga tccaagtgat cgcctacatc ctggccgtcg tgggcctgtc cctgtgtatc 780 gccgcctgca tccctatgca cggccccctg ctgatctccg gcctgtctat tctggccctg 840 gctcagctgc tgggactggt gtacatgaag ttcgtggcct ccaaccagaa aaccatccag 900 ccccctcgga aggccgtgga agaacccctg aacgccttca aagaatccaa gggcatgatg 960 aacgacgaa 969 <210> 42 <211> 323 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(323) <223> CD47 человека <400> 42 Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 1 5 10 15 Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 20 25 30 Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 35 40 45 Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 50 55 60 Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 65 70 75 80 Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 85 90 95 Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 100 105 110 Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 115 120 125 Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 130 135 140 Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 145 150 155 160 Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 165 170 175 Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 180 185 190 Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 195 200 205 Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 210 215 220 Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 225 230 235 240 Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 245 250 255 Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 260 265 270 Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 275 280 285 Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 290 295 300 Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 305 310 315 320 Asn Asp Glu <210> 43 <211> 1509 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1509) <223> SIRP-альфа V3 человека <400> 43 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgt ctgtggccgc tggcgagtct gccatcctgc tgtgtaccgt gacctccctg 180 atccccgtgg gccccatcca gtggtttaga ggcgctggcc ctgccagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgagtccac caagcgcgag 300 aacatggact tctccatctc catcagcaac atcacccctg ccgacgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac accgagttca agtctggcgc tggcaccgag 420 ctgtctgtgc gggctaaacc ttctgcccct gtggtgtctg gacctgccgc tagagctacc 480 cctcagcaca ccgtgtcttt tacctgcgag tcccacggct tcagccctcg ggacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg agcgacttcc agaccaacgt ggaccctgtg 600 ggcgagagcg tgtcctactc catccactcc accgccaagg tggtgctgac acgcgaggac 660 gtgcactccc aagtgatctg cgaggtggcc cacgtgacac tgcagggcga tcctctgaga 720 ggcaccgcca acctgtccga gacaatcaga gtgcccccca ccctggaagt gacccagcag 780 ccagtgcggg ccgagaacca agtgaacgtg acctgccaag tgcggaagtt ctacccccag 840 cggctgcagc tgacctggct ggaaaacggc aatgtgtccc ggaccgagac agccagcacc 900 gtgaccgaga acaaggatgg cacctacaat tggatgtctt ggctgctcgt gaacgtgtcc 960 gcccaccggg acgatgtgaa gctgacatgc caggtggaac acgacggcca gcctgccgtg 1020 tccaagagcc acgatctgaa ggtgtccgct catcccaaag agcagggctc caacaccgcc 1080 gctgagaaca ccggctctaa cgagcggaac atctacatcg tcgtgggcgt cgtgtgcacc 1140 ctgctggtgg ctctgctgat ggctgccctg tacctcgtgc ggatccggca gaagaaggcc 1200 cagggctcta cctcctccac cagactgcac gagcccgaga agaacgccag agagatcacc 1260 caggacacca acgacatcac ctacgccgac ctgaacctgc ccaagggcaa gaagcctgcc 1320 cctcaggctg ccgagcctaa caaccacacc gagtacgcct ccatccagac cagccctcag 1380 cctgcctctg aggacaccct gacctacgct gatctggaca tggtgcacct gaaccggacc 1440 cccaagcagc cagctcctaa gcccgagcct agcttctctg agtacgccag cgtgcaggtg 1500 ccccggaaa 1509 <210> 44 <211> 503 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(503) <223> SIRP-альфа V3 человека <400> 44 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 35 40 45 Glu Ser Ala Ile Leu Leu Cys Thr Val Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 85 90 95 Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 145 150 155 160 Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 260 265 270 Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 305 310 315 320 Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 340 345 350 Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 355 360 365 Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala 370 375 380 Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala 385 390 395 400 Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala 405 410 415 Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn 420 425 430 Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn 435 440 445 His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser Glu 450 455 460 Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg Thr 465 470 475 480 Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr Ala 485 490 495 Ser Val Gln Val Pro Arg Lys 500 <210> 45 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V4 человека <400> 45 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagagggcc tgcaagtgat ccagcccgac 120 aagtccgtgt ctgtggccgc tggcgagtct gccatcctgc actgtaccgc cacctccctg 180 atccccgtgg gacccatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tctccatccg gatcggcaac atcacccctg ccgatgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgaga gcgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagccagtgc gggccgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagcctcc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cttggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggctctgct gatggctgcc ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcccg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ctgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 46 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V4 человека <400> 46 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Gly Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 35 40 45 Glu Ser Ala Ile Leu His Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 47 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V5 человека <400> 47 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagttcgtgc tggtggccgc tggcgagaca gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tctccatccg gatcggcaac atcacccctg ccgatgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgagt ccgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagccagtgc gggccgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gactgcctcc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cttggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggctctgct gatggctgcc ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcccg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ctgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 48 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V5 человека <400> 48 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Phe Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 49 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V6 человека <400> 49 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgc tggtggctgc tggcgagact gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tccccatccg gatcggcaac atcacccctg ccgatgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgagt ccgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagcccgtgc gggctgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagcctcc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cctggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggcactgct gatggccgct ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcccg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ctgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 50 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V6 человека <400> 50 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Pro Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 51 <211> 1509 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1509) <223> SIRP-альфа V8 человека <400> 51 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgc tggtggctgc tggcgagact gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctgccagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgagtccac caagcgcgag 300 aacatggact tctccatctc catcagcaac atcacccctg ccgacgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac accgagttca agtctggcgc tggcaccgag 420 ctgtctgtgc gggctaaacc ttctgcccct gtggtgtctg gacctgccgc tagagctacc 480 cctcagcaca ccgtgtcttt tacctgcgag tcccacggct tcagccctcg ggacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg agcgacttcc agaccaacgt ggaccctgtg 600 ggcgagtccg tgtcctactc catccactcc accgccaagg tggtgctgac acgcgaggac 660 gtgcactccc aagtgatctg cgaggtggcc cacgtgacac tgcagggcga tcctctgaga 720 ggcaccgcca acctgtccga gacaatcaga gtgcccccca ccctggaagt gacccagcag 780 cccgtgcggg ctgagaacca agtgaacgtg acctgccaag tgcggaagtt ctacccccag 840 cggctgcagc tgacctggct ggaaaacggc aatgtgtccc ggaccgagac agccagcacc 900 gtgaccgaga acaaggatgg cacctacaat tggatgtcct ggctgctcgt gaacgtgtcc 960 gcccaccggg acgatgtgaa gctgacatgc caggtggaac acgacggcca gcctgccgtg 1020 tccaagagcc acgatctgaa ggtgtccgct catcccaaag agcagggctc caacaccgcc 1080 gctgagaaca ccggctctaa cgagcggaac atctacatcg tcgtgggcgt cgtgtgcacc 1140 ctgctggtgg cactgctgat ggccgctctg tacctcgtgc ggatccggca gaagaaggcc 1200 cagggctcta cctcctccac cagactgcac gagcccgaga agaacgccag agagatcacc 1260 caggacacca acgacatcac ctacgccgac ctgaacctgc ccaagggcaa gaagcctgcc 1320 cctcaggctg ccgagcctaa caaccacacc gagtacgcct ccatccagac cagccctcag 1380 cctgcctctg aggacaccct gacctacgct gatctggaca tggtgcacct gaaccggacc 1440 cccaagcagc cagctcctaa gcccgagcct agcttctctg agtacgccag cgtgcaggtg 1500 ccccggaaa 1509 <210> 52 <211> 503 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(503) <223> SIRP-альфа V8 человека <400> 52 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 85 90 95 Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 145 150 155 160 Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 260 265 270 Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 305 310 315 320 Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 340 345 350 Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 355 360 365 Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala 370 375 380 Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala 385 390 395 400 Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala 405 410 415 Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn 420 425 430 Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn 435 440 445 His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser Glu 450 455 460 Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg Thr 465 470 475 480 Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr Ala 485 490 495 Ser Val Gln Val Pro Arg Lys 500 <210> 53 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V9 человека <400> 53 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgc tggtggctgc tggcgagact gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tctccatccg gatctccaac atcacccctg ccgacgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgagt ccgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagcccgtgc gggctgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagcctcc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cctggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggcactgct gatggccgct ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcccg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ctgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 54 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V9 человека <400> 54 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 55 <211> 1512 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-бета-C1-альфа-C2-альфа <400> 55 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaggacgagc tgcaagtgat ccagcccgag 120 aagtccgtgt ctgtggccgc tggcgagtct gccaccctga gatgcgctat gacctccctg 180 atccccgtgg gccccatcat gtggtttaga ggcgctggcg ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgagctgac caagcggaac 300 aacctggact tctccatctc catcagcaac atcacccctg ccgacgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggaacc 420 gagctgtccg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgaga gcgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagcctgtgc gggccgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagccagc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cctggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggctctgct gatggctgcc ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcctg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ccgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 56 <211> 504 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-бета-C1-альфа-C2-альфа <400> 56 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Asp 20 25 30 Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly 35 40 45 Glu Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu 85 90 95 Thr Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 57 <211> 1512 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-альфа-C1-бета-C2-альфа <400> 57 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgc tggtggctgc tggcgagact gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tctccatccg gatcggcaac atcacccctg ccgatgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cccgtggtgt ctggacctgc cgtgcgagct 480 acccctgagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccca 600 gccggcgact ccgtgtccta ctccatccac tctaccgcca gagtggtgct gaccagaggc 660 gacgtgcact cccaagtgat ctgcgagatc gcccatatca cactgcaggg cgaccccctg 720 agaggcaccg ctaacctgtc tgagacaatc cgggtgcccc ccaccctgga agtgactcag 780 cagccagtgc gggccgagaa ccaagtgaac gtgacctgcc aagtgcggaa gttctacccc 840 cagcggctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagcctcc 900 accgtgaccg agaacaagga tggcacctac aattggatgt cttggctgct cgtgaacgtg 960 tccgcccacc gggacgatgt gaagctgaca tgccaggtgg aacacgacgg ccagcctgcc 1020 gtgtccaagt cccacgatct gaaggtgtcc gctcatccca aagagcaggg ctccaacacc 1080 gccgctgaga acaccggctc taacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggcactgct gatggccgct ctgtacctcg tgcggatccg gcagaagaag 1200 gcccagggct ctacctcctc caccagactg cacgagcccg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ccgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 58 <211> 504 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-альфа-C1-бета-C2-альфа <400> 58 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala 145 150 155 160 Thr Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 59 <211> 1512 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-альфа-C1-альфа-C2-бета <400> 59 atggaacctg ccggccctgc tcctggtaga ctgggacctc tgctgtgtct gctgctggcc 60 gcctcttgtg cttggagcgg agtggctggc gaagaggaac tgcaagtgat ccagcccgac 120 aagtccgtgc tggtggctgc tggcgagact gccaccctga gatgtaccgc cacctccctg 180 atccccgtgg gccctatcca gtggtttaga ggcgctggcc ctggcagaga gctgatctac 240 aaccagaaag agggccactt ccccagagtg accaccgtgt ccgacctgac caagcggaac 300 aacatggact tctccatccg gatcggcaac atcacccctg ccgatgccgg cacctactac 360 tgcgtgaagt tccggaaggg ctcccccgac gacgtggagt tcaaatccgg cgctggcacc 420 gagctgtctg tgcgggctaa accttctgcc cctgtggtgt ctggccctgc cgctagagct 480 acccctcagc acaccgtgtc ttttacctgc gagtcccacg gcttcagccc tcgggacatc 540 accctgaagt ggttcaagaa cggcaacgag ctgagcgact tccagaccaa cgtggaccct 600 gtgggcgagt ccgtgtccta ctccatccac tccaccgcca aggtggtgct gacacgcgag 660 gacgtgcact cccaagtgat ctgcgaggtg gcccacgtga cactgcaggg cgatcctctg 720 agaggcaccg ccaacctgtc cgagacaatc agagtgcccc ccaccctgga agtgacccag 780 cagcctatga gagccgagaa ccaggccaac gtgacctgcc aggtgtccaa cttctaccct 840 cggggcctgc agctgacctg gctggaaaac ggcaatgtgt cccggaccga gacagcctcc 900 accctgatcg agaacaagga tggcacctac aattggatgt cctggctgct cgtgaacacc 960 tgtgcccacc gggacgatgt ggtgctgacc tgtcaggtgg aacacgatgg ccagcaggcc 1020 gtgtccaagt cctacgctct ggaagtgtcc gcccacccca aagagcaggg ctctaatacc 1080 gccgctgaga acaccggctc caacgagcgg aacatctaca tcgtcgtggg cgtcgtgtgc 1140 accctgctgg tggcactgct gatggccgct ctgtacctcg tgcggatccg gcagaagaag 1200 gctcagggct ccacctcctc caccagactg cacgagcctg agaagaacgc cagagagatc 1260 acccaggaca ccaacgacat cacctacgcc gacctgaacc tgcccaaggg caagaagcct 1320 gcccctcagg ctgccgagcc taacaaccac accgagtacg cctccatcca gaccagccct 1380 cagcctgcct ctgaggacac cctgacctac gctgatctgg acatggtgca cctgaaccgg 1440 acccccaagc agccagctcc taagcccgag cctagcttct ctgagtacgc cagcgtgcag 1500 gtgccccgga aa 1512 <210> 60 <211> 504 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа-V-альфа-C1-альфа-C2-бета <400> 60 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr 260 265 270 Cys Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr 305 310 315 320 Cys Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 61 <211> 1512 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1512) <223> SIRP-альфа V1(P74A) человека <400> 61 atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc 60 gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac 120 aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg 180 atccctgtgg ggcccatcca gtggttcaga ggagctggag caggccggga attaatctac 240 aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac 300 aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac 360 tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact 420 gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc 480 acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc 540 accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc 600 gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag 660 gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt 720 cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa 780 cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc 840 cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca 900 accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta 960 tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg 1020 gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc 1080 gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc 1140 accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa 1200 gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata 1260 acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct 1320 gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg 1380 cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg 1440 acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag 1500 gtcccgagga ag 1512 <210> 62 <211> 504 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(504) <223> SIRP-альфа V1(P74A) человека <400> 62 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 63 <211> 321 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(321) <223> Константный домен каппа человека <400> 63 cggaccgtgg ccgctccctc cgtgttcatc ttcccacctt ccgacgagca gctgaagtcc 60 ggcaccgctt ctgtcgtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag 120 tggaaggtgg acaacgccct gcagtccggc aactcccagg aatccgtgac cgagcaggac 180 tccaaggaca gcacctactc cctgtcctcc accctgaccc tgtccaaggc cgactacgag 240 aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc tgtgaccaag 300 tccttcaacc ggggcgagtg c 321 <210> 64 <211> 107 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(107) <223> Константный домен каппа человека <400> 64 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 65 <211> 981 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(981) <223> Константные домены IgG4 человека (включающие S228P) <400> 65 gcttccacca agggcccctc cgtgtttcct ctggcccctt gctccagatc cacctccgag 60 tctaccgccg ctctgggctg cctcgtgaag gactacttcc ccgagcctgt gacagtgtcc 120 tggaactctg gcgccctgac ctctggcgtg cacacctttc cagctgtgct gcagtcctcc 180 ggcctgtact ccctgtccag cgtcgtgaca gtgccctcca gctctctggg caccaagacc 240 tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggaatct 300 aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accttctgtg 360 tttctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc 420 tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac 480 ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac 540 cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag 600 tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaaa agaccatctc caaggccaag 660 ggccagcccc gggaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag 720 aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa 780 tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc 840 gacggctcct tctttctgta ctctcgcctg accgtggaca agtcccggtg gcaggaaggc 900 aacgtgttct cctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc 960 ctgtccctgt ctctgggaaa a 981 <210> 66 <211> 327 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(327) <223> Константные домены IgG4 человека (включающие S228P) <400> 66 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 67 <211> 978 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(978) <223> Константные домены IgG2 человека <220> <221> misc_feature <222> (769)..(769) <223> n представляет собой g или t <400> 67 gcttctacaa agggccccag cgtgttccct ctggctcctt gtagcagaag caccagcgag 60 tctacagccg ctctgggctg tctggtcaag gactactttc ccgagcctgt gaccgtgtcc 120 tggaatagcg gagcactgac aagcggcgtg cacacctttc cagctgtgct gcaaagctcc 180 ggcctgtact ctctgtccag cgtggtcaca gtgcccagca gcaattttgg cacccagacc 240 tacacctgta atgtggacca caagcctagc aacaccaagg tggacaagac cgtggaacgg 300 aagtgctgcg tggaatgccc tccttgtcct gctcctccag tggctggccc ttccgtgttt 360 ctgttccctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgc 420 gtggtggtgg atgtgtccca cgaggatcct gaggtgcagt tcaattggta cgtggacggc 480 gtggaagtgc acaacgccaa gaccaagcct agagaggaac agttcaacag caccttcaga 540 gtggtgtccg tgctgaccgt ggtgcatcag gattggctga acggcaaaga gtacaagtgc 600 aaggtgtcca acaagggcct gcctgctcct atcgagaaaa ccatcagcaa gaccaaaggc 660 cagcctcgcg agccccaggt ttacacactt cctccaagcc gggaagagat gaccaagaac 720 caggtgtccc tgacctgcct cgtgaagggc ttctacccca gcgacatcnc cgtggaatgg 780 gagagcaatg gccagcctga gaacaactac aagaccacac ctcctatgct ggactccgac 840 ggctcattct tcctgtacag caagctgaca gtggacaagt ccagatggca gcagggcaac 900 gtgttctcct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg 960 tctctgagcc ccggcaaa 978 <210> 68 <211> 326 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(326) <223> Константные домены IgG2 человека <220> <221> misc_feature <222> (257)..(257) <223> X представляет собой A или S <400> 68 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 100 105 110 Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 115 120 125 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 130 135 140 Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 145 150 155 160 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 165 170 175 Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 180 185 190 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 195 200 205 Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 210 215 220 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 225 230 235 240 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 245 250 255 Xaa Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 260 265 270 Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 275 280 285 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 290 295 300 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 305 310 315 320 Ser Leu Ser Pro Gly Lys 325 <210> 69 <211> 5 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR1 тяжелой цепи 40A <400> 69 Ser Tyr Trp Met His 1 5 <210> 70 <211> 17 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR2 тяжелой цепи 40A <400> 70 Ala Ile Tyr Pro Val Asn Asn Asp Thr Thr Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> 71 <211> 13 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR3 тяжелой цепи 40A <400> 71 Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr 1 5 10 <210> 72 <211> 11 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR1 легкой цепи 40A <400> 72 Arg Ala Ser Gln Asp Ile Gly Ser Arg Leu Asn 1 5 10 <210> 73 <211> 7 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR2 легкой цепи 40A <400> 73 Ala Thr Ser Ser Leu Asp Ser 1 5 <210> 74 <211> 9 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: CDR3 легкой цепи 40A <400> 74 Leu Gln Tyr Ala Ser Ser Pro Phe Thr 1 5 <210> 75 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Вариабельная область тяжелой цепи гуманизированного антитела 40 (консенсусная последовательность) <220> <221> misc_feature <222> (4)..(4) <223> X = F или L <220> <221> misc_feature <222> (5)..(5) <223> X = Q, или R, или V <220> <221> misc_feature <222> (10)..(10) <223> X = E или V <220> <221> misc_feature <222> (11)..(11) <223> X = L или V <220> <221> misc_feature <222> (12)..(12) <223> X = A, или K, или V <220> <221> misc_feature <222> (20)..(20) <223> X = L, или M, или V <220> <221> misc_feature <222> (38)..(38) <223> X = K или R <220> <221> misc_feature <222> (40)..(40) <223> X = A, или R, или T <220> <221> misc_feature <222> (48)..(48) <223> X = I или M <220> <221> misc_feature <222> (67)..(67) <223> X = K или R <220> <221> misc_feature <222> (68)..(68) <223> X = A или V <220> <221> misc_feature <222> (70)..(70) <223> X = L или M <220> <221> misc_feature <222> (73)..(73) <223> X = D или V <220> <221> misc_feature <222> (74)..(74) <223> X = K или T <220> <221> misc_feature <222> (76)..(76) <223> X = A, или S, или T <220> <221> misc_feature <222> (79)..(79) <223> X = A или V <220> <221> misc_feature <222> (82)..(82) <223> X = E или Q <220> <221> misc_feature <222> (87)..(87) <223> X = R или T <220> <221> misc_feature <222> (88)..(88) <223> X = F или S <220> <221> misc_feature <222> (91)..(91) <223> X = S или T <220> <221> misc_feature <222> (97)..(97) <223> X = A или T <220> <221> misc_feature <222> (117)..(117) <223> X = L или T <220> <221> misc_feature <222> (118)..(118) <223> X = L или V <400> 75 Glu Val Gln Xaa Xaa Gln Ser Gly Ala Xaa Xaa Xaa Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Xaa Gln Xaa Pro Gly Gln Gly Leu Glu Trp Xaa 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Xaa Xaa Thr Xaa Thr Val Xaa Xaa Ser Xaa Ser Thr Xaa Tyr 65 70 75 80 Met Xaa Leu Ser Ser Leu Xaa Xaa Glu Asp Xaa Ala Val Tyr Tyr Cys 85 90 95 Xaa Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Xaa Xaa Thr Val Ser Ser 115 120 <210> 76 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Вариабельная область легкой цепи гуманизированного антитела 40 (консенсусная последовательность) <220> <221> misc_feature <222> (15)..(15) <223> X = L или V <220> <221> misc_feature <222> (17)..(17) <223> X = D или E <220> <221> misc_feature <222> (20)..(20) <223> X = S или T <220> <221> misc_feature <222> (39)..(39) <223> X = K или T <220> <221> misc_feature <222> (44)..(44) <223> X = I или P <220> <221> misc_feature <222> (60)..(60) <223> X = K или S <220> <221> misc_feature <222> (66)..(66) <223> X = G или R <220> <221> misc_feature <222> (69)..(69) <223> X = S или T <220> <221> misc_feature <222> (70)..(70) <223> X = D или E <220> <221> misc_feature <222> (71)..(71) <223> X = F или Y <220> <221> misc_feature <222> (72)..(72) <223> X = S или T <220> <221> misc_feature <222> (77)..(77) <223> X = G или S <220> <221> misc_feature <222> (100)..(100) <223> X = G или Q <220> <221> misc_feature <222> (104)..(104) <223> X = L или V <220> <221> misc_feature <222> (107)..(107) <223> X = H или K <400> 76 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Xaa Gly 1 5 10 15 Xaa Arg Val Xaa Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Xaa Pro Gly Lys Ala Xaa Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Xaa Arg Phe Ser Gly 50 55 60 Ser Xaa Ser Gly Xaa Xaa Xaa Xaa Leu Thr Ile Ser Xaa Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Xaa 100 105 <210> 77 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH1 hSIRP-альфа.40A <400> 77 gaggtgcagt tcttgcagtc tggtgccgtg ctggctagac ctggaacctc cgtgaagatc 60 tcctgcaagg cctccggctc caccttcacc tcttactgga tgcactgggt caagcagagg 120 cctggacagg gactcgaatg gatcggcgct ctgtaccctg tgaactccga caccacctac 180 aaccagaagt tcaagggcag agccaagctg accgtggcca cctctgcttc tatcgcctac 240 ctggaatttt ccagcctgac caacgaggac tccgccgtgt actactgcgc ccggtccttc 300 tactactctc tggacgccgc ttggtttgtg tactggggcc agggaactct ggtgaccgtg 360 tcctct 366 <210> 78 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH1 hSIRP-альфа.40A <400> 78 Glu Val Gln Phe Leu Gln Ser Gly Ala Val Leu Ala Arg Pro Gly Thr 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Leu Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Arg Ala Lys Leu Thr Val Ala Thr Ser Ala Ser Ile Ala Tyr 65 70 75 80 Leu Glu Phe Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 79 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH2 hSIRP-альфа.40A <400> 79 gaggtgcagc tggttcagtc tggcgctgag gttgtgaagc ctggcgcttc cgtgaagctg 60 tcctgcaagg cttctggctc caccttcacc agctactgga tgcactgggt caagcaggcc 120 cctggacaag gcctggaatg gatcggcgct atctaccccg tgaactccga caccacctac 180 aaccagaagt tcaagggcaa agctaccctg accgtggaca agtctgcctc caccgcctac 240 atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac ccggtccttc 300 tactactccc tggacgccgc ttggtttgtg tattggggcc agggaacact ggtgaccgtg 360 tcctct 366 <210> 80 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH2 hSIRP-альфа.40A <400> 80 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 81 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH3 hSIRP-альфа.40A <400> 81 gaggtgcagc tgagacagtc tggcgctgtg cttgtgaagc ctggcgcctc cgtgaagatg 60 tcctgcaagg cttctggctc caccttcacc agctactgga tgcactgggt caagcagacc 120 cctggacagg gactcgagtg gatcggcgct atctaccctg tgaactccga caccacctac 180 aaccagaagt tcaagggcaa agctaccctg accgtggaca agtcctcctc caccgcttac 240 atgcagctgt ccagcctgac ctctgaggac tccgccgtgt actactgcgc ccggtccttc 300 tactactctc tggacgccgc ttggtttgtg tactggggcc agggcacaac cctgacagtg 360 tcctct 366 <210> 82 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH3 hSIRP-альфа.40A <400> 82 Glu Val Gln Leu Arg Gln Ser Gly Ala Val Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 115 120 <210> 83 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH4 hSIRP-альфа.40A <400> 83 gaggtgcagt tcgttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg cttctggctc caccttcacc agctactgga tgcactgggt ccgacaggct 120 ccaggacaag gcttggaatg gatgggcgct atctaccccg tgaactccga caccacctac 180 aaccagaaat tcaagggcag agtgaccatg accgtcgtga cctccacctc caccgtgtac 240 atggaactgt ccagcctgag atccgaggac accgccgtgt actactgcgc ccggtccttc 300 tactactctc tggacgccgc ttggtttgtg tactggggcc agggaactct ggtgaccgtg 360 tcctct 366 <210> 84 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH4 hSIRP-альфа.40A <400> 84 Glu Val Gln Phe Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Arg Val Thr Met Thr Val Val Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 85 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH5 hSIRP-альфа.40A <400> 85 gaggtccagc tgcaacagtc tggtgccgtg ttggctaagc ctggcgcctc cgtgaagatg 60 tcctgcaagg cttctggctc caccttcacc agctactgga tgcactgggt caagcagagg 120 cctggacagg gactcgagtg gatcggcgct atctaccctg tgaactccga caccacctac 180 aaccagaagt tcaagggcaa agctaccctg accgtggaca agtcctcctc caccgcttac 240 atgcagctgt ccagcctgac cttcgaggac tccgccgtgt actactgcgc ccggtccttc 300 tactactctc tggacgccgc ttggtttgtg tactggggcc agggcacaac cctgacagtg 360 tcctct 366 <210> 86 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH5 hSIRP-альфа.40A <400> 86 Glu Val Gln Leu Gln Gln Ser Gly Ala Val Leu Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 115 120 <210> 87 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH6 hSIRP-альфа.40A <400> 87 gaggtgcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg cttctggctc caccttcacc agctactgga tgcactgggt ccgacaggct 120 ccaggacaag gcttggaatg gatgggcgct atctaccccg tgaactccga caccacctac 180 aaccagaaat tcaagggcag agtgaccatg accgtggaca cctccaccag caccgtgtac 240 atggaactgt ccagcctgag atccgaggac accgccgtgt actactgcgc ccggtccttc 300 tactactctc tggacgccgc ttggtttgtg tactggggcc agggaactct ggtgaccgtg 360 tcctct 366 <210> 88 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH6 hSIRP-альфа.40A <400> 88 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Val Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 89 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL1 hSIRP-альфа.40A <400> 89 gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagacccct 120 ggcaaggcca tcaagagact gatctacgcc acctccagcc tggattctgg cgtgccctct 180 agattctccg gctctagatc tggcaccgac ttctccctga ccatctctgg actgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgccagct ctccattcac ctttggcgga 300 ggcaccaagg tggaaatcca c 321 <210> 90 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL1 hSIRP-альфа.40A <400> 90 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Thr Pro Gly Lys Ala Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile His 100 105 <210> 91 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL2 hSIRP-альфа.40A <400> 91 gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagaagcct 120 ggcaaggcca tcaagagact gatctacgcc acctccagcc tggattctgg cgtgccctct 180 agattctccg gctctagatc tggcaccgac tttaccctga caatcagctc cctgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgcctcct ctccattcac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 92 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL2 hSIRP-альфа.40A <400> 92 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 93 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL3 hSIRP-альфа.40A <400> 93 gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagaagcct 120 ggcaaggcca tcaagagact gatctacgcc acctccagcc tggattctgg cgtgccctct 180 agattctccg gctctagatc tggcaccgac tttaccctga caatcagctc cctgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgccagct ctccattcac ctttggcgga 300 ggcaccaagc tggaaatcaa g 321 <210> 94 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL3 hSIRP-альфа.40A <400> 94 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 95 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL4 hSIRP-альфа.40A <400> 95 gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagaagcct 120 ggcaaggccc ctaagagact gatctacgcc acctccagcc tggattctgg cgtgccctct 180 agattctccg gctctggctc tggcaccgag tttaccctga caatcagctc cctgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgccagct ctccattcac ctttggcgga 300 ggcaccaagg tggaaatcaa g 321 <210> 96 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL4 hSIRP-альфа.40A <400> 96 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 97 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL5 hSIRP-альфа.40A <400> 97 gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagaagcct 120 ggcaaggcca tcaagagact gatctacgcc acctccagcc tggattctgg cgtgcccaag 180 agattctccg gctctagatc cggctccgac tataccctga caatcagctc cctgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgcctcct ctccattcac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 98 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL5 hSIRP-альфа.40A <400> 98 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 99 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL6 hSIRP-альфа.40A <400> 99 gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga gagagtgtcc 60 atcacctgta gagcctctca ggacatcggc tccagactga actggctgca gcagaagcct 120 ggcaaggcca tcaagagact gatctacgcc acctccagcc tggattctgg cgtgccctct 180 agattctccg gctctagatc tggcaccgac tttaccctga caatcagctc cctgcagcct 240 gaggacttcg ccacctacta ctgtctgcag tacgccagct ctccattcac ctttggcgga 300 ggcaccaagg tggaaatcaa g 321 <210> 100 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL6 hSIRP-альфа.40A <400> 100 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 101 <211> 366 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VH мыши hSIRP-альфа.40A <400> 101 gaggttcagt tccagcagtc tgggactgtg ctggcaaggc cagggacttc agtgaagatg 60 tcctgcaagg cttctggctc cacctttacc agctactgga tgcactgggt aaaacagggg 120 cctggacagg gtctgcaatg gattggcgct atttatcctg taaataatga tactacctat 180 aatcagaagt tcaagggcaa ggccgaactc actgtagtca cttccaccag cactgcctac 240 atggaggtca gtagtctgac aaatgaggac tctgcggtct attactgtac aagatcgttc 300 tactatagtc tcgacgcggc ctggtttgtt tactggggcc aagggactct ggtcactgtc 360 tctgca 366 <210> 102 <211> 122 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH мыши hSIRP-альфа.40A <400> 102 Glu Val Gln Phe Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Thr 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Gly Pro Gly Gln Gly Leu Gln Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Val Asn Asn Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Glu Leu Thr Val Val Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Val Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ala 115 120 <210> 103 <211> 321 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: VL мыши hSIRP-альфа.40A <400> 103 gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 60 ctcacttgtc gggcaagtca ggacattggt agtaggttaa actggcttca gcaggaacca 120 gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa 180 aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcgg ccttgagtct 240 gaagactttg tagactatta ctgtctacaa tatgctagtt ctccgttcac gttcggaggg 300 gggaccaagc tggaaataaa c 321 <210> 104 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL мыши hSIRP-альфа.40A <400> 104 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Gly Leu Glu Ser 65 70 75 80 Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn 100 105 <210> 105 <211> 446 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Тяжелая цепь мыши hSIRP-альфа.40A <400> 105 Glu Val Gln Phe Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Thr 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Ser Tyr 20 25 30 Trp Met His Trp Val Lys Gln Gly Pro Gly Gln Gly Leu Gln Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Val Asn Asn Asp Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Glu Leu Thr Val Val Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Val Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Phe Tyr Tyr Ser Leu Asp Ala Ala Trp Phe Val Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 115 120 125 Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 130 135 140 Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 180 185 190 Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 195 200 205 Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 210 215 220 Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 225 230 235 240 Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 245 250 255 Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 260 265 270 Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 275 280 285 Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 290 295 300 Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 305 310 315 320 Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 340 345 350 Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 355 360 365 Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 370 375 380 Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 385 390 395 400 Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 405 410 415 Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 420 425 430 Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 435 440 445 <210> 106 <211> 214 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: Легкая цепь мыши hSIRP-альфа.40A <400> 106 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 20 25 30 Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Gly Leu Glu Ser 65 70 75 80 Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Asp Ala Ala 100 105 110 Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 115 120 125 Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 130 135 140 Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 145 150 155 160 Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 165 170 175 Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 180 185 190 Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 195 200 205 Phe Asn Arg Asn Glu Cys 210 <210> 107 <211> 581 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: rhSIRP-альфа/Fc <400> 107 Gly Val Ala Gly Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser 1 5 10 15 Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr 20 25 30 Ser Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro 35 40 45 Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val 50 55 60 Thr Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile 65 70 75 80 Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val 85 90 95 Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala 100 105 110 Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser 115 120 125 Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys 130 135 140 Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys 145 150 155 160 Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly 165 170 175 Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr 180 185 190 Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr 195 200 205 Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile 210 215 220 Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu 225 230 235 240 Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg 245 250 255 Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr 260 265 270 Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser 275 280 285 Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr 290 295 300 Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp 305 310 315 320 Leu Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala 325 330 335 Glu Asn Thr Gly Ser Asn Glu Arg Ile Glu Gly Arg Met Asp Pro Lys 340 345 350 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 355 360 365 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 370 375 380 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 385 390 395 400 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 405 410 415 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 420 425 430 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 435 440 445 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 450 455 460 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 465 470 475 480 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 485 490 495 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 500 505 510 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 515 520 525 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 530 535 540 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 545 550 555 560 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 565 570 575 Leu Ser Pro Gly Lys 580 <210> 108 <211> 538 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: rhSIRP-гамма/Fc <400> 108 Val Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn 1 5 10 15 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr 20 25 30 Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro 35 40 45 Ala Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 50 55 60 Glu Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly 65 70 75 80 Ala Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr 85 90 95 Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 100 105 110 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 115 120 125 Phe Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile 130 135 140 Arg Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln 145 150 155 160 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 165 170 175 Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 180 185 190 Val Thr Gln Gln Pro Met Arg Ala Gly Asn Gln Val Asn Val Thr Cys 195 200 205 Gln Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Leu Glu 210 215 220 Asn Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn 225 230 235 240 Lys Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser 245 250 255 Asp Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly 260 265 270 Gln Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln 275 280 285 Lys Asp Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ile Glu Gly 290 295 300 Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 305 310 315 320 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 325 330 335 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 340 345 350 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 355 360 365 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 370 375 380 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 385 390 395 400 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 405 410 415 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 420 425 430 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 435 440 445 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 450 455 460 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 465 470 475 480 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 485 490 495 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 500 505 510 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 515 520 525 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 530 535 <210> 109 <211> 358 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: rhCD47/Fc <400> 109 Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 1 5 10 15 Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 20 25 30 Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 35 40 45 Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 50 55 60 Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 65 70 75 80 Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 85 90 95 Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 100 105 110 Tyr Arg Val Val Ser Trp Phe Ser Pro Ile Glu Gly Arg Met Asp Pro 115 120 125 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 130 135 140 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 145 150 155 160 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 165 170 175 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 180 185 190 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 195 200 205 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 210 215 220 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 225 230 235 240 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 245 250 255 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 260 265 270 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 275 280 285 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 290 295 300 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 305 310 315 320 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 325 330 335 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 340 345 350 Ser Leu Ser Pro Gly Lys 355 <210> 110 <211> 1197 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-гамма-C1-бета-C2-бета <400> 110 atgcccgtgc ctgcctcttg gcctcatctg cccagcccct ttctgctgat gaccctgctg 60 ctgggcaggc tgacaggcgt ggcaggcgaa gaggaactgc agatgatcca gcccgagaag 120 ctgctgctcg tgaccgtggg caagaccgcc accctgcact gcaccgtgac atccctgctg 180 cctgtgggac ccgtgctgtg gtttagaggc gtgggccctg gcagagagct gatctacaac 240 cagaaagagg gccacttccc cagagtgacc accgtgtccg acctgaccaa gcggaacaac 300 atggacttct ccatccggat ctccagcatc acccctgccg acgtgggcac ctactactgc 360 gtgaagttcc ggaagggctc ccccgagaac gtggagttca agtctggccc aggcaccgag 420 atggccctgg gcgctaaacc ttctgcccct gtggtgtctg gacctgccgt gcgggctacc 480 cctgagcaca ccgtgtcttt tacctgcgag tcccacggct tcagccctcg ggacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg tccgacttcc agaccaacgt ggaccctgcc 600 ggcgactccg tgtcctactc catccactct accgccagag tggtgctgac cagaggcgac 660 gtgcactccc aagtgatctg cgagatcgcc catatcacac tgcagggcga ccccctgaga 720 ggcaccgcca atctgtctga ggccatcaga gtgcccccca ccctggaagt gacccagcag 780 cctatgagag ccgagaacca ggccaacgtg acctgtcagg tgtccaactt ctaccctcgg 840 ggcctgcagc tgacctggct ggaaaacggc aatgtgtccc ggaccgagac agcctccacc 900 ctgatcgaga acaaggacgg cacctacaat tggatgtcct ggctgctcgt gaacacctgt 960 gcccacaggg acgacgtggt gctgacatgc caggtggaac acgatggcca gcaggccgtg 1020 tccaagtcct acgccctgga aatctccgcc catcagaaag agcacggctc cgatatcacc 1080 cacgaggccg ctctggctcc taccgctcct ctgctggtgg ctctgctgct gggacctaag 1140 ctgctgctgg tcgtgggcgt gtccgccatc tacatctgct ggaagcagaa ggcctga 1197 <210> 111 <211> 398 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-гамма-C1-бета-C2-бета <400> 111 Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 1 5 10 15 Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Glu Glu 20 25 30 Leu Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys 35 40 45 Thr Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro 50 55 60 Val Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn 65 70 75 80 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr 85 90 95 Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro 100 105 110 Ala Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 115 120 125 Glu Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 145 150 155 160 Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 260 265 270 Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 305 310 315 320 Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 340 345 350 Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 355 360 365 Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 370 375 380 Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 385 390 395 <210> 112 <211> 1197 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-бета-C1-гамма-C2-бета <400> 112 atgcccgtgc ctgcctcttg gcctcatctg cccagcccct ttctgctgat gaccctgctg 60 ctgggcaggc tgacaggcgt ggcaggcgaa gatgagctgc aagtgatcca gcccgagaag 120 tccgtgtctg tggccgctgg cgagtctgcc accctgagat gcgctatgac ctccctgatc 180 cccgtgggcc ccatcatgtg gtttagaggc gctggcgctg gcagagagct gatctacaac 240 cagaaagagg gccacttccc cagagtgacc accgtgtccg agctgaccaa gcggaacaac 300 ctggacttct ccatctccat cagcaacatc acccctgccg acgccggcac ctactactgc 360 gtgaagttcc ggaagggctc ccccgacgac gtggagttca aatccggcgc tggaaccgag 420 ctgtccgtgc gggctaaacc ttctgcccct gtggtgctgg gacctgccgc tagaaccacc 480 cctgagcaca ccgtgtcttt tacctgcgag tcccacggct tcagccctcg ggacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg agcgacttcc agaccaacgt ggaccctacc 600 ggccagtccg tggcctactc catcagatcc accgccagag tggtgctgga cccttgggat 660 gtgcggtccc aagtgatctg cgaggtggcc catgtgacac tgcagggcga tcctctgaga 720 ggcaccgcca atctgtctga ggccatcaga gtgcccccca ccctggaagt gacccagcag 780 cctatgagag ccgagaacca ggccaacgtg acctgccagg tgtccaactt ctaccctcgg 840 ggcctgcagc tgacctggct ggaaaacggc aatgtgtccc ggaccgagac agcctccacc 900 ctgatcgaga acaaggatgg cacctacaat tggatgtcct ggctgctcgt gaacacctgt 960 gcccaccggg atgacgtggt gctgacttgt caggtggaac acgacggcca gcaggccgtg 1020 tccaagtcct acgccctgga aatctccgcc catcagaaag agcacggctc cgatatcacc 1080 cacgaggccg ctctggctcc taccgctcct ctgctggtgg ctctgctgct gggacctaag 1140 ctgctgctgg tcgtgggcgt gtccgccatc tacatctgct ggaagcagaa ggcctga 1197 <210> 113 <211> 398 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-бета-C1-гамма-C2-бета <400> 113 Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 1 5 10 15 Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 20 25 30 Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 35 40 45 Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 50 55 60 Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 65 70 75 80 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 85 90 95 Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 100 105 110 Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 115 120 125 Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr 145 150 155 160 Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile 195 200 205 Arg Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln 210 215 220 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 260 265 270 Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 305 310 315 320 Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 340 345 350 Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 355 360 365 Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 370 375 380 Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 385 390 395 <210> 114 <211> 1197 <212> ДНК <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-бета-C1-бета-C2-гамма <400> 114 atgcccgtgc ctgcctcttg gcctcatctg cccagcccct ttctgctgat gaccctgctg 60 ctgggcaggc tgacaggcgt ggcaggcgaa gatgagctgc aagtgatcca gcccgagaag 120 tccgtgtctg tggccgctgg cgagtctgcc accctgagat gcgctatgac ctccctgatc 180 cccgtgggcc ccatcatgtg gtttagaggc gctggcgctg gcagagagct gatctacaac 240 cagaaagagg gccacttccc cagagtgacc accgtgtccg agctgaccaa gcggaacaac 300 ctggacttct ccatctccat cagcaacatc acccctgccg acgccggcac ctactactgc 360 gtgaagttcc ggaagggctc ccccgacgac gtggagttca aatccggcgc tggaaccgag 420 ctgtccgtgc gggctaaacc ttctgcccct gtggtgtctg gacctgctgt gcgcgctacc 480 cctgagcaca ccgtgtcttt tacctgcgag tcccacggct tcagccctcg ggacatcacc 540 ctgaagtggt tcaagaacgg caacgagctg agcgacttcc agaccaacgt ggaccctgcc 600 ggcgactccg tgtcctactc catccactct accgccagag tggtgctgac cagaggcgac 660 gtgcactccc aagtgatctg cgagatcgcc catatcacac tgcagggcga ccccctgaga 720 ggcaccgcca atctgtctga ggccatcaga gtgcccccca ccctggaagt gacccagcag 780 cctatgagag tgggcaacca agtgaacgtg acctgccaag tgcggaagtt ctacccccag 840 tccctgcagc tgacttggag cgagaatggc aacgtgtgcc agagagagac agcctccacc 900 ctgaccgaga acaaggacgg aacctacaac tggacctcct ggttcctcgt gaacatctcc 960 gaccagcggg acgacgtggt gctgacatgc caagtgaagc acgatggaca gctggccgtg 1020 tccaagcggc tggctctgga agtgacagtg caccagaaag agcacggctc cgacatcacc 1080 cacgaggccg ctctggctcc tacagctcct ctgctggtgg ctctgctgct gggacctaag 1140 ctgctgctgg tcgtgggcgt gtccgccatc tacatctgct ggaagcagaa ggcctga 1197 <210> 115 <211> 398 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-V-бета-C1-бета-C2-гамма <400> 115 Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 1 5 10 15 Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 20 25 30 Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 35 40 45 Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 50 55 60 Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 65 70 75 80 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 85 90 95 Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 100 105 110 Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 115 120 125 Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 145 150 155 160 Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys 260 265 270 Gln Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu 275 280 285 Asn Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser 305 310 315 320 Asp Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly 325 330 335 Gln Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln 340 345 350 Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 355 360 365 Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 370 375 380 Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 385 390 395 <210> 116 <211> 1194 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(1194) <223> SIRP-бета L человека <400> 116 atgcctgtgc ctgcctcttg gcctcatctg ccctctccat ttctgctgat gaccctgctg 60 ctgggcagac tgacaggtgt tgctggcgaa gaggaactgc aagtgatcca gcctgacaag 120 agcatctctg tggccgctgg cgaatctgcc acactgcact gtaccgtgac atctctgatc 180 cctgtgggcc ccatccagtg gtttagaggt gctggacctg gcagagagct gatctacaac 240 cagaaagagg gacacttccc cagagtgacc accgtgtccg acctgaccaa gcggaacaac 300 atggacttca gcatccggat cagcaacatc acccctgccg atgccggcac ctactactgc 360 gtgaagttca gaaagggcag ccccgaccac gtcgagttta aaagcggagc cggcacagag 420 ctgagcgtgc gggctaaacc ttctgctcct gtggtgtctg gaccagccgc tagagctaca 480 cctcagcaca ccgtgtcttt tacctgcgag agccacggct tcagccccag agatatcacc 540 ctgaagtggt tcaagaacgg caacgagctg tccgacttcc agaccaatgt ggacccagcc 600 ggcgatagcg tgtcctacag cattcacagc accgccaagg tggtgctgac ccgggaagat 660 gtgcacagcc aagtgatttg cgaggtggcc cacgttaccc tgcaaggcga tcctctgaga 720 ggaaccgcca acctgagcga gacaatccgg gtgccaccta cactggaagt gacccagcag 780 cctgtgcggg ccgagaatca agtgaacgtg acctgccaag tgcggaagtt ctaccctcag 840 agactgcagc tgacctggct ggaaaacggc aatgtgtccc ggaccgagac agccagcaca 900 ctgaccgaga acaaggatgg cacctacaat tggatgagct ggctgctggt caatgtgtct 960 gcccaccggg acgatgtgaa gctgacatgc caggtggaac acgatggcca gcctgccgtg 1020 tctaagagcc acgacctgaa ggtgtccgct catcccaaag agcagggcag caatactgcc 1080 cctggacctg ctcttgcttc tgccgctcct ctgctgatcg cctttctgct gggacctaag 1140 gtgctgctgg ttgtgggagt gtccgtgatc tacgtgtact ggaagcagaa ggcc 1194 <210> 117 <211> 398 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(398) <223> SIRP-бета L человека <400> 117 Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 1 5 10 15 Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Glu Glu 20 25 30 Leu Gln Val Ile Gln Pro Asp Lys Ser Ile Ser Val Ala Ala Gly Glu 35 40 45 Ser Ala Thr Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly Pro 50 55 60 Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr Asn 65 70 75 80 Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr 85 90 95 Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn Ile Thr Pro 100 105 110 Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 115 120 125 Asp His Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 130 135 140 Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 145 150 155 160 Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 165 170 175 Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 180 185 190 Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 195 200 205 His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 210 215 220 Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 225 230 235 240 Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 245 250 255 Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 260 265 270 Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 275 280 285 Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Thr Glu Asn 290 295 300 Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 305 310 315 320 Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 325 330 335 Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 340 345 350 Lys Glu Gln Gly Ser Asn Thr Ala Pro Gly Pro Ala Leu Ala Ser Ala 355 360 365 Ala Pro Leu Leu Ile Ala Phe Leu Leu Gly Pro Lys Val Leu Leu Val 370 375 380 Val Gly Val Ser Val Ile Tyr Val Tyr Trp Lys Gln Lys Ala 385 390 395 <210> 118 <211> 990 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(990) <223> Константные домены IgG1 человека <400> 118 gccagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggtaaa 990 <210> 119 <211> 330 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(330) <223> Константные домены IgG1 человека <400> 119 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 120 <211> 336 <212> ПРТ <213> Mus musculus <220> <221> misc_feature <222> (1)..(336) <223> Константные домены IgG1 мыши <400> 120 Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly 1 5 10 15 Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 20 25 30 Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 35 40 45 Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met 50 55 60 Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 65 70 75 80 Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys 85 90 95 Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys 100 105 110 Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser 115 120 125 Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu 130 135 140 Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 145 150 155 160 Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 165 170 175 Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val 180 185 190 Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 195 200 205 Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr 210 215 220 Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu 225 230 235 240 Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys 245 250 255 Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser 260 265 270 Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp 275 280 285 Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser 290 295 300 Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly 305 310 315 320 Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 325 330 335 <210> 121 <211> 107 <212> ПРТ <213> Mus musculus <220> <221> misc_feature <222> (1)..(107) <223> Константный домен каппа мыши <400> 121 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 1 5 10 15 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 20 25 30 Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 35 40 45 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 65 70 75 80 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 85 90 95 Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 100 105 <210> 122 <211> 326 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(326) <223> Константные домены IgG2 человека, мутант V234A-G237A-P238S-H268A-V309L-A330S-P331S (Sigma) <220> <221> misc_feature <222> (257)..(257) <223> X представляет собой A или S <400> 122 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 100 105 110 Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 115 120 125 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 130 135 140 Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 145 150 155 160 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 165 170 175 Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 180 185 190 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 195 200 205 Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 210 215 220 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 225 230 235 240 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 245 250 255 Xaa Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 260 265 270 Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 275 280 285 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 290 295 300 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 305 310 315 320 Ser Leu Ser Pro Gly Lys 325 <210> 123 <211> 330 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(330) <223> Константные домены IgG1 человека, мутант L234A-L235A <400> 123 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 124 <211> 990 <212> ДНК <213> Homo sapiens <220> <221> misc_feature <222> (1)..(990) <223> Константные домены IgG1 человека, мутант L234A-L235A-P329G <400> 124 gctagcacaa agggccctag tgtgtttcct ctggctccct cttccaaatc cacttctggt 60 ggcactgctg ctctgggatg cctggtgaag gattactttc ctgaacctgt gactgtctca 120 tggaactctg gtgctctgac ttctggtgtc cacactttcc ctgctgtgct gcagtctagt 180 ggactgtact ctctgtcatc tgtggtcact gtgccctctt catctctggg aacccagacc 240 tacatttgta atgtgaacca caaaccatcc aacactaaag tggacaaaaa agtggaaccc 300 aaatcctgtg acaaaaccca cacctgccca ccttgtccgg cgcctgaagc ggcgggagga 360 ccttctgtgt ttctgttccc ccccaaacca aaggataccc tgatgatctc gcgaacccct 420 gaggtgacat gtgtggtggt ggatgtgtct catgaggacc ccgaagtcaa atttaattgg 480 tatgtcgacg gcgtcgaggt gcataatgcc aaaaccaagc ctagagagga acagtacaat 540 tcaacctaca gagtcgtcag tgtgctgact gtgctgcatc aggattggct gaatggcaag 600 gaatacaagt gtaaagtctc aaacaaggcc ctgggagctc caattgagaa aacaatctca 660 aaggccaaag gacagcctag ggaaccccag gtctacaccc tgccaccttc gagagacgaa 720 ctgaccaaaa accaggtgtc cctgacatgc ctggtcaaag gcttctaccc ttctgacatt 780 gctgtggagt gggagtcaaa tggacagcct gagaacaact acaaaacaac cccccctgtg 840 ctggattctg atggctcttt ctttctgtac tccaaactga ctgtggacaa gtctagatgg 900 cagcagggga atgtcttttc ttgctctgtc atgcatgagg ctctgcataa ccactacact 960 cagaaatccc tgtctctgtc tcccgggaaa 990 <210> 125 <211> 330 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(330) <223> Константные домены IgG1 человека, мутант L234A-L235A-P329G <400> 125 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 126 <211> 330 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(330) <223> Константные домены IgG1 человека, мутант N297Q <400> 126 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 127 <211> 327 <212> ПРТ <213> Homo sapiens <220> <221> misc_feature <222> (1)..(327) <223> Константные домены IgG4 человека, мутант S228P-N297Q <400> 127 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 128 <211> 120 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH 18D5 <400> 128 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ala 115 120 <210> 129 <211> 112 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL 18D5 <400> 129 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 130 <211> 113 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VH KWAR23 <400> 130 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 20 25 30 Tyr Ile His Trp Val Gln Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 131 <211> 108 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: VL KWAR23 <400> 131 Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 20 25 30 Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 35 40 45 Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 65 70 75 80 Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro 85 90 95 Arg Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 100 105 <210> 132 <211> 376 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: rhSIRP-альфа-HIS <400> 132 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg His His His His His His 370 375 <210> 133 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа V1 <400> 133 Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 1 5 10 15 Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 20 25 30 Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 35 40 45 Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 50 55 60 Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 100 105 <210> 134 <211> 106 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-альфа V2 <400> 134 Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 1 5 10 15 Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 20 25 30 Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 35 40 45 Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 50 55 60 Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly 100 105 <210> 135 <211> 107 <212> ПРТ <213> Искусственная последовательность <220> <223> Синтетическая: hSIRP-бета 1 <400> 135 Glu Asp Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala 1 5 10 15 Ala Gly Glu Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro 20 25 30 Val Gly Pro Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu 35 40 45 Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 50 55 60 Glu Leu Thr Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 100 105