ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> IDD BIOTECH (INTERNATIONAL - DRUG - DEVELOPMENT - BIOTECH) <120> Лечение В-клеточных злокачественных новообразований с использованием афукозилированных проапоптотических анти-CD19 антител в сочетании с анти-CD20 антителами или химиотерапевтическими средствами <130> BET17L2270 <160> 44 <170> версия PatentIn 3.5 <210> 1 <211> 330 <212> БЕЛОК <213> искусственная последовательность <220> <223> Fc34 <400> 1 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Pro Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Leu Arg Val Val Ser Leu Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Ala Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Leu Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 2 <211> 993 <212> ДНК <213> искусственная последовательность <220> <223> Fc34 <400> 2 gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttacc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgccggagga gcagtacaac 540 agcacgctcc gtgtggtcag cctcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacgcagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctctcgtg 840 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggtaaa tga 993 <210> 3 <211> 330 <212> БЕЛОК <213> искусственная последовательность <220> <223> Fc24 <400> 3 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Pro Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Leu Arg Val Val Ser Leu Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Leu Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 4 <211> 993 <212> ДНК <213> искусственная последовательность <220> <223> Fc24 <400> 4 gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttacc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgccggagga gcagtacaac 540 agcacgctcc gtgtggtcag cctcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacgcagcc ctcccagccc ccatcgcgaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctctcgtg 840 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggtaaa tga 993 <210> 5 <211> 8 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 5 Gly Tyr Ala Phe Ser Ser Tyr Trp 1 5 <210> 6 <211> 8 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 6 Ile Tyr Pro Gly Asp Gly Asp Thr 1 5 <210> 7 <211> 14 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 7 Ala Arg Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr 1 5 10 <210> 8 <211> 6 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 8 Asp His Ile Asn Asn Trp 1 5 <210> 9 <211> 3 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 9 Gly Ala Thr 1 <210> 10 <211> 9 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 10 Gln Gln Ser Trp Asn Thr Pro Trp Thr 1 5 <210> 11 <211> 5 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 11 Ser Tyr Trp Val Asn 1 5 <210> 12 <211> 17 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 12 Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 1 5 10 15 Gly <210> 13 <211> 12 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 13 Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr 1 5 10 <210> 14 <211> 11 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 14 Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 1 5 10 <210> 15 <211> 7 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 15 Gly Ala Thr Thr Leu Glu Thr 1 5 <210> 16 <211> 4 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 16 Ser Ser Tyr Trp 1 <210> 17 <211> 8 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 17 Gly Tyr Thr Phe Thr Ser Tyr Val 1 5 <210> 18 <211> 8 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 18 Val Asn Pro Tyr Asn Asp Gly Thr 1 5 <210> 19 <211> 14 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 19 Ala Arg Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr 1 5 10 <210> 20 <211> 11 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 20 Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr 1 5 10 <210> 21 <211> 3 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 21 Arg Val Ser 1 <210> 22 <211> 9 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 22 Leu Gln Val Thr His Val Pro Pro Thr 1 5 <210> 23 <211> 5 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 23 Ser Tyr Val Met His 1 5 <210> 24 <211> 17 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 24 Tyr Val Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 25 <211> 12 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 25 Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr 1 5 10 <210> 26 <211> 16 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 26 Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr Leu Asn 1 5 10 15 <210> 27 <211> 7 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 27 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 28 <211> 4 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 28 Thr Ser Tyr Val 1 <210> 29 <211> 121 <212> БЕЛОК <213> искусственная последовательность <220> <223> белок <400> 29 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Val Asn Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Arg Ala Thr Val Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 65 70 75 80 Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Ser Val Thr Val Ser Ser 115 120 <210> 30 <211> 363 <212> ДНК <213> искусственная последовательность <220> <223> ДНК <400> 30 caggtccagc tgcagcagtc tggggctgaa ctggtgaggc ctgggtcctc agtgaagatt 60 tcctgtaagg cttctggcta tgcattcagt agctactggg tgaactggat gaagcagagg 120 cctggacagg gacttgagtg gattggacag atttaccctg gagatggtga tactaattac 180 aatggaaagt tcaagggtcg agccacagtg actgcagaca aatcctccag cacatcctac 240 atgcagttca gcagcctaac atctgaggac tctgcggtct atttctgtgc aagatctatt 300 actacggtgg taggctgtgc tatggactac tggggtcaag gaacctcggt caccgtctcc 360 tca 363 <210> 31 <211> 103 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 31 Asp Ile Gln Met Thr Gln Ser Ser Ala Tyr Leu Ser Val Ser Leu Gly 1 5 10 15 Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 35 40 45 Ser Gly Ala Thr Thr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn Thr Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys 100 <210> 32 <211> 309 <212> ДНК <213> искусственная последовательность <220> <223> ДНК <400> 32 gacattcaga tgacccagtc ttctgcctac ctgtctgtat ctctaggagg cagggtcacc 60 attacttgca aggcaagtga ccacattaat aattggttag cctggtatca acataaacca 120 ggaaatgctc ctaggctctt aatatctggt gcaaccactt tggaaactgg ggttccttca 180 agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact 240 gaagatgttg ctacttatta ctgtcaacag tcttggaata ctccgtggac gttcggtgga 300 ggcaccaag 309 <210> 33 <211> 120 <212> БЕЛОК <213> искусственная последовательность <220> <223> белок <400> 33 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Val Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Gln Val Thr Val Ser Ser 115 120 <210> 34 <211> 360 <212> ДНК <213> искусственная последовательность <220> <223> ДНК <400> 34 gaggttcagc tgcaacagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg 60 tcctgcaagg cttctggata cacattcact agctatgtta tgcactgggt gaagcagaag 120 cctgggcagg gccttgagtg gattggatat gttaatcctt acaatgatgg tactaagtac 180 aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac 240 atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagagggcct 300 tattactacg gtagtagccc ctttgactac tggggccaag gccaggtcac cgtctcctca 360 <210> 35 <211> 108 <212> БЕЛОК <213> искусственная последовательность <220> <223> белок <400> 35 Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 85 90 95 Thr His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys 100 105 <210> 36 <211> 324 <212> ДНК <213> искусственная последовательность <220> <223> ДНК <400> 36 gacgctgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60 atctcttgca ggtctagtca gagccttgaa aacagtaatg gaaacaccta tttgaactgg 120 tacctccaga aaccaggcca gtctccacag ctcctgatct acagggtttc caaccgattt 180 tctggggtcc tagacaggtt cagtggtagt ggatcaggga cagatttcac actgaaaatc 240 agcagagtgg aggctgagga tttgggagtt tatttctgcc tccaagttac acatgtccct 300 cccacgttcg gtgctgggac caag 324 <210> 37 <211> 214 <212> БЕЛОК <213> искусственная последовательность <220> <223> L-IDD001 <400> 37 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile Asn Asn Trp 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ser Gly Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn Thr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 38 <211> 642 <212> ДНК <213> искусственная последовательность <220> <223> L-IDD001 <400> 38 gacatacaaa tgacacaatc tcccgctagc cttagtgcat cagttggcgg ccgagttacc 60 atcacatgca aagctagcca aagcatcaac aactggctgg cttggtatca gcacaagccc 120 ggtaaggcac ctaagctgct catctctggg gcatctactc tggagagtgg tgtgccatcc 180 cgattttccg ggtctggaag cggaaaggac tatacactga ccatcagcag tttgcaacct 240 gaagacgttg ccacttatta ctgccaacag tcctggaata caccctggac cttcggccaa 300 gggaccaagg tggagatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca 360 tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420 cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480 gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540 ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600 ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt 642 <210> 39 <211> 451 <212> БЕЛОК <213> искусственная последовательность <220> <223> H-IDD001 <400> 39 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Val Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 145 150 155 160 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165 170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu Leu Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285 His Asn Ala Lys Thr Lys Pro Pro Glu Glu Gln Tyr Asn Ser Thr Leu 290 295 300 Arg Val Val Ser Leu Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile 325 330 335 Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Leu 385 390 395 400 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410 415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445 Pro Gly Lys 450 <210> 40 <211> 1353 <212> ДНК <213> искусственная последовательность <220> <223> H-IDD001 <400> 40 caagttcaat tggttcagtc tggtgctgag gtaaagaagc ctggaagtag tgtgaaggtg 60 agttgtaaag catctggata cgctttttcc agttattggg tgaactgggt gaagcaggca 120 cccggtcagg gactggagtg gatgggtagg atctatcccg gggacggaga cacaaactac 180 gctcagaagt tccagggacg cgtgactatt accgccgaca aaagtacttc caccgcatat 240 atggagctgt cttctttgag gtccgaagat accgctgtgt actactgcgc aagatccatc 300 accacagtgg tcggttgcgc tatggattat tggggccagg gtactctcgt gacagtcagt 360 tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 420 gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 480 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 540 tcaggactct actccctcag cagcgtcgtg accgtgccct ccagcagctt gggcacccag 600 acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag 660 cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg 720 ggaccgtcag tcttcctctt acccccaaaa cccaaggaca ccctcatgat ctcccggacc 780 cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 840 tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgccgga ggagcagtac 900 aacagcacgc tccgtgtggt cagcctcctc accgtcctgc accaggactg gctgaatggc 960 aaggagtaca agtgcaaggt ctccaacgca gccctcccag cccccatcgc gaaaaccatc 1020 tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat 1080 gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac 1140 atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctctc 1200 gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg 1260 tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 1320 acgcagaaga gcctctccct gtctccgggt aaa 1353 <210> 41 <211> 6 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 41 Gln Ser Ile Asn Asn Trp 1 5 <210> 42 <211> 11 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 42 Lys Ala Ser Gln Ser Ile Asn Asn Trp Leu Ala 1 5 10 <210> 43 <211> 3 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 43 Gly Ala Ser 1 <210> 44 <211> 7 <212> БЕЛОК <213> искусственная последовательность <220> <223> пептид <400> 44 Gly Ala Ser Thr Leu Glu Thr 1 5