ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> Общество с ограниченной ответственностью "ЭйДжиСиТи" <120> TAL-ЭФФЕКТОРНАЯ НУКЛЕАЗА ДЛЯ ЦЕЛЕВОГО НОКАУТА ВИЧ-КОРЕЦЕПТОРА CCR5 <130> PAT 1473 PCT <150> DE102014106327.9 <151> 2014-05-07 <160> 18 <170> BiSSAP 1.3 <210> 1 <211> 19 <212> ДНК <213> Homo sapiens <400> 1 gctggtcatc ctcatcctg 19 <210> 2 <211> 19 <212> ДНК <213> Homo sapiens <400> 2 agatgtcagt catgctctt 19 <210> 3 <211> 1071 <212> ПРТ <213> Искусственная последовательность <220> <223> CCR5-Uco-L <400> 3 Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 1 5 10 15 Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 20 25 30 Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu Gly Tyr 35 40 45 Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 50 55 60 Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 65 70 75 80 Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 85 90 95 Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 100 105 110 Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 115 120 125 Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 130 135 140 Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 145 150 155 160 Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 165 170 175 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys 180 185 190 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 195 200 205 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 210 215 220 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 225 230 235 240 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 245 250 255 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 260 265 270 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 275 280 285 Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 290 295 300 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 305 310 315 320 Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 325 330 335 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 340 345 350 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 355 360 365 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 370 375 380 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 385 390 395 400 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 405 410 415 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 420 425 430 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 435 440 445 Leu Thr Pro Glu Gln Val Val Ala Ile Val Ser Asn Gly Gly Gly Lys 450 455 460 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 465 470 475 480 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 485 490 495 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 500 505 510 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 515 520 525 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 530 535 540 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 545 550 555 560 Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 565 570 575 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 580 585 590 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 595 600 605 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 610 615 620 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 625 630 635 640 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 645 650 655 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 660 665 670 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 675 680 685 Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 690 695 700 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 705 710 715 720 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 725 730 735 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 740 745 750 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 755 760 765 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 770 775 780 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 785 790 795 800 Asn Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 805 810 815 Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 820 825 830 Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 835 840 845 Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu 850 855 860 Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu 865 870 875 880 Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 885 890 895 Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg 900 905 910 Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 915 920 925 Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 930 935 940 Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 945 950 955 960 Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 965 970 975 Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 980 985 990 Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 995 1000 1005 Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 1010 1015 1020 Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu 1025 1030 1035 1040 Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu 1045 1050 1055 Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg Ser 1060 1065 1070 <210> 4 <211> 1071 <212> PRT <213> Искусственная последовательность <220> <223> CCR5-Uco-R <400> 4 Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 1 5 10 15 Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 20 25 30 Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu Gly Tyr 35 40 45 Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 50 55 60 Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 65 70 75 80 Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 85 90 95 Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 100 105 110 Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 115 120 125 Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 130 135 140 Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 145 150 155 160 Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 165 170 175 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 180 185 190 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 195 200 205 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 210 215 220 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 225 230 235 240 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 245 250 255 Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 260 265 270 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 275 280 285 Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 290 295 300 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 305 310 315 320 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 325 330 335 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 340 345 350 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 355 360 365 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 370 375 380 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 385 390 395 400 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 405 410 415 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 420 425 430 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 435 440 445 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys 450 455 460 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 465 470 475 480 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 485 490 495 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 500 505 510 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 515 520 525 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 530 535 540 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 545 550 555 560 Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 565 570 575 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 580 585 590 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 595 600 605 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 610 615 620 Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val 625 630 635 640 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 645 650 655 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 660 665 670 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 675 680 685 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 690 695 700 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 705 710 715 720 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 725 730 735 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 740 745 750 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 755 760 765 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 770 775 780 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 785 790 795 800 Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 805 810 815 Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 820 825 830 Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 835 840 845 Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu 850 855 860 Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu 865 870 875 880 Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 885 890 895 Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg 900 905 910 Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 915 920 925 Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 930 935 940 Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 945 950 955 960 Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 965 970 975 Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 980 985 990 Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 995 1000 1005 Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 1010 1015 1020 Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu 1025 1030 1035 1040 Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu 1045 1050 1055 Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg Ser 1060 1065 1070 <210> 5 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 4 <223> Xaa = Любая аминокислота, или E, Q, D или A <220> <221> SITE <222> 10 <223> Xaa = Любая аминокислота, или A или V <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <220> <221> SITE <222> 32 <223> Xaa = Любая аминокислота, или A или D <400> 5 Leu Thr Pro Xaa Gln Val Val Ala Ile Xaa Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Xaa 20 25 30 His Gly <210> 6 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <400> 6 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly <210> 7 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <400> 7 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly <210> 8 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <400> 8 Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 20 25 30 His Gly <210> 9 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <400> 9 Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 20 25 30 His Gly <210> 10 <211> 34 <212> ПРТ <213> Искусственная последовательность <220> <223> TALEN-единица повтора <220> <221> SITE <222> 12..13 <223> Вариабельные последовательности из двух аминокислотных остатков (RVD) <400> 10 Leu Thr Pro Glu Gln Val Val Ala Ile Val Ser Xaa Xaa Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly <210> 11 <211> 1059 <212> ДНК <213> Homo sapiens <220> <223> hCCR5 ДНК <400> 11 atggattatc aagtgtcaag tccaatctat gacatcaatt attatacatc ggagccctgc 60 caaaaaatca atgtgaagca aatcgcagcc cgcctcctgc ctccgctcta ctcactggtg 120 ttcatctttg gttttgtggg caacatgctg gtcatcctca tcctgataaa ctgcaaaagg 180 ctgaagagca tgactgacat ctacctgctc aacctggcca tctctgacct gtttttcctt 240 cttactgtcc ccttctgggc tcactatgct gccgcccagt gggactttgg aaatacaatg 300 tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc 360 ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt aaaagccagg 420 acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt gtttgcgtct 480 ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac ctgcagctct 540 cattttccat acagtcagta tcaattctgg aagaatttcc agacattaaa gatagtcatc 600 ttggggctgg tcctgccgct gcttgtcatg gtcatctgct actcgggaat cctaaaaact 660 ctgcttcggt gtcgaaatga gaagaagagg cacagggctg tgaggcttat cttcaccatc 720 atgattgttt attttctctt ctgggctccc tacaacattg tccttctcct gaacaccttc 780 caggaattct ttggcctgaa taattgcagt agctctaaca ggttggacca agctatgcag 840 gtgacagaga ctcttgggat gacgcactgc tgcatcaacc ccatcatcta tgcctttgtc 900 ggggagaagt tcagaaacta cctcttagtc ttcttccaaa agcacattgc caaacgcttc 960 tgcaaatgct gttctatttt ccagcaagag gctcccgagc gagcaagctc agtttacacc 1020 cgatccactg gggagcagga aatatctgtg ggcttgtga 1059 <210> 12 <211> 198 <212> ПРТ <213> Planomicrobium okeanokoites <220> <223> FokI - домен расщепления <400> 12 Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 1 5 10 15 Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 20 25 30 Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 35 40 45 Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 50 55 60 Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 65 70 75 80 Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 85 90 95 Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 100 105 110 Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 115 120 125 Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 130 135 140 Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 145 150 155 160 Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 165 170 175 Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 180 185 190 Glu Ile Asn Phe Arg Ser 195 <210> 13 <211> 1037 <212> ПРТ <213> Искусственная последовательность <220> <223> CCR5-Mco-L <400> 13 Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 1 5 10 15 Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 20 25 30 Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu Gly Tyr 35 40 45 Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 50 55 60 Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 65 70 75 80 Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 85 90 95 Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 100 105 110 Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 115 120 125 Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 130 135 140 Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 145 150 155 160 Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 165 170 175 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 180 185 190 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 195 200 205 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 210 215 220 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 225 230 235 240 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 245 250 255 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 260 265 270 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 275 280 285 Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 290 295 300 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 305 310 315 320 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 325 330 335 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 340 345 350 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 355 360 365 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 370 375 380 Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 385 390 395 400 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 405 410 415 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 420 425 430 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 435 440 445 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 450 455 460 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 465 470 475 480 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 485 490 495 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 500 505 510 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 515 520 525 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 530 535 540 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 545 550 555 560 Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 565 570 575 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 580 585 590 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 595 600 605 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 610 615 620 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 625 630 635 640 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 645 650 655 Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 660 665 670 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 675 680 685 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 690 695 700 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 705 710 715 720 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 725 730 735 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 740 745 750 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 755 760 765 Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 770 775 780 Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys 785 790 795 800 Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His 805 810 815 Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr 820 825 830 Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 835 840 845 Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 850 855 860 Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 865 870 875 880 Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 885 890 895 Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 900 905 910 Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 915 920 925 Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 930 935 940 Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 945 950 955 960 Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 965 970 975 Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 980 985 990 His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 995 1000 1005 Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 1010 1015 1020 Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg Ser 1025 1030 1035 <210> 14 <211> 1037 <212> ПРТ <213> Искусственная последовательность <220> <223> CCR5-Mco-R <400> 14 Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 1 5 10 15 Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 20 25 30 Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu Gly Tyr 35 40 45 Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 50 55 60 Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 65 70 75 80 Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 85 90 95 Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 100 105 110 Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 115 120 125 Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 130 135 140 Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 145 150 155 160 Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 165 170 175 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 180 185 190 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 195 200 205 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 210 215 220 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 225 230 235 240 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 245 250 255 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 260 265 270 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 275 280 285 Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 290 295 300 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 305 310 315 320 Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 325 330 335 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 340 345 350 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 355 360 365 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 370 375 380 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 385 390 395 400 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 405 410 415 Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 420 425 430 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 435 440 445 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 450 455 460 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 465 470 475 480 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 485 490 495 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 500 505 510 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 515 520 525 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 530 535 540 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 545 550 555 560 Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 565 570 575 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 580 585 590 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 595 600 605 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 610 615 620 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 625 630 635 640 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 645 650 655 Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 660 665 670 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 675 680 685 Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 690 695 700 Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 705 710 715 720 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 725 730 735 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 740 745 750 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 755 760 765 Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 770 775 780 Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys 785 790 795 800 Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His 805 810 815 Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr 820 825 830 Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 835 840 845 Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 850 855 860 Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 865 870 875 880 Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 885 890 895 Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 900 905 910 Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 915 920 925 Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 930 935 940 Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 945 950 955 960 Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 965 970 975 Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 980 985 990 His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 995 1000 1005 Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 1010 1015 1020 Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg Ser 1025 1030 1035 <210> 15 <211> 18 <212> ДНК <213> Homo sapiens <400> 15 gtgggcaaca tgctggtc 18 <210> 16 <211> 18 <212> ПРТ <213> Homo sapiens <400> 16 Cys Thr Thr Cys Ala Gly Cys Cys Thr Thr Thr Thr Gly Cys Ala Gly 1 5 10 15 Thr Thr <210> 17 <211> 3788 <212> ДНК <213> Искусственная последовательность <220> <223> CCR5-Uco-L mRNA <400> 17 ggggccacca uggacuauaa ggaccacgac ggagacuaca aggaucauga uauugauuac 60 aaagacgaug acgauaagau ggccccaaag aagaagcgga aggucgguau ccacggaguc 120 ccagcagccg uagauuugag aacuuuggga uauucacagc agcagcagga aaagaucaag 180 cccaaaguga ggucgacagu cgcgcagcau cacgaagcgc ugguggguca uggguuuaca 240 caugcccaca ucguagccuu gucgcagcac ccugcagccc uuggcacggu cgccgucaag 300 uaccaggaca ugauugcggc guugccggaa gccacacaug aggcgaucgu cggugugggg 360 aaacagugga gcggagcccg agcgcuugag gcccuguuga cggucgcggg agagcugaga 420 gggccucccc uucagcugga cacgggccag uugcugaaga ucgcgaagcg gggaggaguc 480 acggcggucg aggcggugca cgcguggcgc aaugcgcuca cgggagcacc ccucaaccug 540 accccagagc aggucguggc aauugcgagc aaccacgggg gaaagcaggc acucgaaacc 600 guccagaggu ugcugccugu gcugugccaa gcgcacggac uuacgccaga gcaggucgug 660 gcaauugcga gccaugacgg gggaaagcag gcacucgaaa ccguccagag guugcugccu 720 gugcugugcc aagcgcacgg acuaacccca gagcaggucg uggcaauugc gagcaacgga 780 gggggaaagc aggcacucga aaccguccag agguugcugc cugugcugug ccaagcgcac 840 ggguugaccc cagagcaggu cguggcaauu gcgagcaacc acgggggaaa gcaggcacuc 900 gaaaccgucc agagguugcu gccugugcug ugccaagcgc acggccugac cccagagcag 960 gucguggcaa uugcgagcaa ccacggggga aagcaggcac ucgaaaccgu ccagagguug 1020 cugccugugc ugugccaagc gcacggacug acaccagagc aggucguggc aauugcgagc 1080 aacggagggg gaaagcaggc acucgaaacc guccagaggu ugcugccugu gcugugccaa 1140 gcgcacggac uuacacccga acaagucgug gcaauugcga gccaugacgg gggaaagcag 1200 gcacucgaaa ccguccagag guugcugccu gugcugugcc aagcgcacgg acuuacgcca 1260 gagcaggucg uggcaauugc gagcaacauc gggggaaagc aggcacucga aaccguccag 1320 agguugcugc cugugcugug ccaagcgcac ggacuaaccc cagagcaggu cguggcaauu 1380 gugagcaacg gagggggaaa gcaggcacuc gaaaccgucc agagguugcu gccugugcug 1440 ugccaagcgc acggguugac cccagagcag gucguggcaa uugcgagcca ugacggggga 1500 aagcaggcac ucgaaaccgu ccagagguug cugccugugc ugugccaagc gcacggccug 1560 accccagagc aggucguggc aauugcgagc caugacgggg gaaagcaggc acucgaaacc 1620 guccagaggu ugcugccugu gcugugccaa gcgcacggac ugacaccaga gcaggucgug 1680 gcaauugcga gcaacggagg gggaaagcag gcacucgaaa ccguccagag guugcugccu 1740 gugcugugcc aagcgcacgg ccucacccca gagcaggucg uggcaauugc gagccaugac 1800 gggggaaagc aggcacucga aaccguccag agguugcugc cugugcugug ccaagcgcac 1860 ggacuuacgc cagagcaggu cguggcaauu gcgagcaaca ucgggggaaa gcaggcacuc 1920 gaaaccgucc agagguugcu gccugugcug ugccaagcgc acggacuaac cccagagcag 1980 gucguggcaa uugcgagcaa cggaggggga aagcaggcac ucgaaaccgu ccagagguug 2040 cugccugugc ugugccaagc gcacggguug accccagagc aggucguggc aauugcgagc 2100 caugacgggg gaaagcaggc acucgaaacc guccagaggu ugcugccugu gcugugccaa 2160 gcgcacggcc ugaccccaga gcaggucgug gcaauugcga gccaugacgg gggaaagcag 2220 gcacucgaaa ccguccagag guugcugccu gugcugugcc aagcgcacgg acugacacca 2280 gagcaggucg uggcaauugc gagcaacgga gggggaaagc aggcacucga aaccguccag 2340 agguugcugc cugugcugug ccaagcgcac ggacucacgc cugagcaggu aguggcuauu 2400 gcauccaaca acgggggcag acccgcacug gagucaaucg uggcccagcu uucgaggccg 2460 gaccccgcgc uggccgcacu cacuaaugau caucuuguag cgcuggccug ccucggcgga 2520 cgacccgccu uggaugcggu gaagaagggg cucccgcacg cgccugcauu gauuaagcgg 2580 accaacagaa ggauucccga gaggacauca caucgagugg cagguuccca acucgugaag 2640 agugaacuug aggagaaaaa gucggagcug cggcacaaau ugaaauacgu accgcaugaa 2700 uacaucgaac uuaucgaaau ugcuaggaac ucgacucaag acagaauccu ugagaugaag 2760 guaauggagu ucuuuaugaa gguuuaugga uaccgaggga agcaucucgg uggaucacga 2820 aaacccgacg gagcaaucua uacggugggg agcccgauug auuacggagu gaucgucgac 2880 acgaaagccu acagcggugg guacaaucuu cccaucgggc aggcagauga gaugcaacgu 2940 uaugucgaag aaaaucagac caggaacaaa cacaucaauc caaaugagug guggaaagug 3000 uauccuucau cagugaccga guuuaaguuu uuguuugucu cugggcauuu caaaggcaac 3060 uauaaggccc agcucacacg guugaaucac auuacgaacu gcaauggugc gguuuugucc 3120 guagaggaac ugcucauugg uggagaaaug aucaaagcgg gaacucugac acuggaagaa 3180 gucagacgca aguuuaacaa uggcgagauc aauuuccgcu cauaaaaaau cagccucgac 3240 ugugccuucu aguugccagc caucuguugu uugccccucc cccgugccuu ccuugacccu 3300 ggaaggugcc acucccacug uccuuuccua auaaaaugag gaaauugcau cacaacacuc 3360 aacccuaucu cggucuauuc uuuugauuua uaagggauuu ugccgauuuc ggccuauugg 3420 uuaaaaaaug agcugauuua acaaaaauuu aacgcgaauu aauucugugg aauguguguc 3480 aguuagggug uggaaagucc ccaggcuccc cagcaggcag aaguaugcaa agcaugcauc 3540 ucaauuaguc agcaaccagg uguggaaagu ccccaggcuc cccagcaggc agaaguaugc 3600 aaagcaugca ucucaauuag ucagcaacca uagucccgcc ccuaacuccg cccaucccgc 3660 cccuaacucc gcccaguucc gcccauucuc cgccccaugg cugacuaauu uuuuuuauuu 3720 augcagaggc cgaggccgcc ucugccucug agcuauucca gaaguaguga ggaggcuuuu 3780 uuggaggc 3788 <210> 18 <211> 3788 <212> ДНК <213> Искусственная последовательность <220> <223> CCR5-Uco-R mRNA <400> 18 ggggccacca uggacuauaa ggaccacgac ggagacuaca aggaucauga uauugauuac 60 aaagacgaug acgauaagau ggccccaaag aagaagcgga aggucgguau ccacggaguc 120 ccagcagccg uagauuugag aacuuuggga uauucacagc agcagcagga aaagaucaag 180 cccaaaguga ggucgacagu cgcgcagcau cacgaagcgc ugguggguca uggguuuaca 240 caugcccaca ucguagccuu gucgcagcac ccugcagccc uuggcacggu cgccgucaag 300 uaccaggaca ugauugcggc guugccggaa gccacacaug aggcgaucgu cggugugggg 360 aaacagugga gcggagcccg agcgcuugag gcccuguuga cggucgcggg agagcugaga 420 gggccucccc uucagcugga cacgggccag uugcugaaga ucgcgaagcg gggaggaguc 480 acggcggucg aggcggugca cgcguggcgc aaugcgcuca cgggagcacc ccucaaccug 540 accccagagc aggucguggc aauugcgagc aacaucgggg gaaagcaggc acucgaaacc 600 guccagaggu ugcugccugu gcugugccaa gcgcacggac uuacgccaga gcaggucgug 660 gcaauugcga gcaacaacgg gggaaagcag gcacucgaaa ccguccagag guugcugccu 720 gugcugugcc aagcgcacgg acuaacccca gagcaggucg uggcaauugc gagcaacauc 780 gggggaaagc aggcacucga aaccguccag agguugcugc cugugcugug ccaagcgcac 840 ggguugaccc cagagcaggu cguggcaauu gcgagcaacg gagggggaaa gcaggcacuc 900 gaaaccgucc agagguugcu gccugugcug ugccaagcgc acggccugac cccagagcag 960 gucguggcaa uugcgagcaa caacggggga aagcaggcac ucgaaaccgu ccagagguug 1020 cugccugugc ugugccaagc gcacggacug acaccagagc aggucguggc aauugcgagc 1080 aacggagggg gaaagcaggc acucgaaacc guccagaggu ugcugccugu gcugugccaa 1140 gcgcacggac uuacacccga acaagucgug gcaauugcga gccaugacgg gggaaagcag 1200 gcacucgaaa ccguccagag guugcugccu gugcugugcc aagcgcacgg acuuacgcca 1260 gagcaggucg uggcaauugc gagcaacauc gggggaaagc aggcacucga aaccguccag 1320 agguugcugc cugugcugug ccaagcgcac ggacuaaccc cagagcaggu cguggcaauu 1380 gcgagcaacc acgggggaaa gcaggcacuc gaaaccgucc agagguugcu gccugugcug 1440 ugccaagcgc acggguugac cccagagcag gucguggcaa uugcgagcaa cggaggggga 1500 aagcaggcac ucgaaaccgu ccagagguug cugccugugc ugugccaagc gcacggccug 1560 accccagagc aggucguggc aauugcgagc caugacgggg gaaagcaggc acucgaaacc 1620 guccagaggu ugcugccugu gcugugccaa gcgcacggac ugacaccaga gcaggucgug 1680 gcaauugcga gcaacaucgg gggaaagcag gcacucgaaa ccguccagag guugcugccu 1740 gugcugugcc aagcgcacgg ccucacccca gagcaggucg uggcaauugc gagcaacgga 1800 gggggaaagc aggcacucga aaccguccag agguugcugc cugugcugug ccaagcgcac 1860 ggacuuacgc cagagcaggu cguggcaauu gcgagcaacc acgggggaaa gcaggcacuc 1920 gaaaccgucc agagguugcu gccugugcug ugccaagcgc acggacuaac cccagagcag 1980 gucguggcaa uugcgagcca ugacggggga aagcaggcac ucgaaaccgu ccagagguug 2040 cugccugugc ugugccaagc gcacggguug accccagagc aggucguggc aauugcgagc 2100 aacggagggg gaaagcaggc acucgaaacc guccagaggu ugcugccugu gcugugccaa 2160 gcgcacggcc ugaccccaga gcaggucgug gcaauugcga gccaugacgg gggaaagcag 2220 gcacucgaaa ccguccagag guugcugccu gugcugugcc aagcgcacgg acugacacca 2280 gagcaggucg uggcaauugc gagcaacgga gggggaaagc aggcacucga aaccguccag 2340 agguugcugc cugugcugug ccaagcgcac ggacucacgc cugagcaggu aguggcuauu 2400 gcauccaacg gagggggcag acccgcacug gagucaaucg uggcccagcu uucgaggccg 2460 gaccccgcgc uggccgcacu cacuaaugau caucuuguag cgcuggccug ccucggcgga 2520 cgacccgccu uggaugcggu gaagaagggg cucccgcacg cgccugcauu gauuaagcgg 2580 accaacagaa ggauucccga gaggacauca caucgagugg cagguuccca acucgugaag 2640 agugaacuug aggagaaaaa gucggagcug cggcacaaau ugaaauacgu accgcaugaa 2700 uacaucgaac uuaucgaaau ugcuaggaac ucgacucaag acagaauccu ugagaugaag 2760 guaauggagu ucuuuaugaa gguuuaugga uaccgaggga agcaucucgg uggaucacga 2820 aaacccgacg gagcaaucua uacggugggg agcccgauug auuacggagu gaucgucgac 2880 acgaaagccu acagcggugg guacaaucuu cccaucgggc aggcagauga gaugcaacgu 2940 uaugucgaag aaaaucagac caggaacaaa cacaucaauc caaaugagug guggaaagug 3000 uauccuucau cagugaccga guuuaaguuu uuguuugucu cugggcauuu caaaggcaac 3060 uauaaggccc agcucacacg guugaaucac auuacgaacu gcaauggugc gguuuugucc 3120 guagaggaac ugcucauugg uggagaaaug aucaaagcgg gaacucugac acuggaagaa 3180 gucagacgca aguuuaacaa uggcgagauc aauuuccgcu cauaaaaaau cagccucgac 3240 ugugccuucu aguugccagc caucuguugu uugccccucc cccgugccuu ccuugacccu 3300 ggaaggugcc acucccacug uccuuuccua auaaaaugag gaaauugcau cacaacacuc 3360 aacccuaucu cggucuauuc uuuugauuua uaagggauuu ugccgauuuc ggccuauugg 3420 uuaaaaaaug agcugauuua acaaaaauuu aacgcgaauu aauucugugg aauguguguc 3480 aguuagggug uggaaagucc ccaggcuccc cagcaggcag aaguaugcaa agcaugcauc 3540 ucaauuaguc agcaaccagg uguggaaagu ccccaggcuc cccagcaggc agaaguaugc 3600 aaagcaugca ucucaauuag ucagcaacca uagucccgcc ccuaacuccg cccaucccgc 3660 cccuaacucc gcccaguucc gcccauucuc cgccccaugg cugacuaauu uuuuuuauuu 3720 augcagaggc cgaggccgcc ucugccucug agcuauucca gaaguaguga ggaggcuuuu 3780 uuggaggc 3788